Non-steroidal and steroidal anti-inflammatory drugs vary in their modulation of dendritic cell function in the elicitation phase of allergic contact dermatitis

Experimental Dermatology
W BäumerM Kietzmann

Abstract

The role of dendritic cells (DCs) in allergic contact dermatitis has been clearly demonstrated for the induction phase. However, the situation during the elicitation phase is very complex within a distinct inflammatory response. This study was performed to exploit DC migration in the elicitation phase in a mouse model of allergic contact dermatitis and to evaluate the effects of steroidal and non-steroidal anti-inflammatory drugs (NSAIDs) on DC migration through skin in the elicitation phase of allergic contact dermatitis. Topically and systemically administered acetylsalicylic acid (ASA) did not reduce the inflammatory response. However, systemically administered ASA significantly reduced the DC migration to the draining lymph node. In contrast, topically administered indomethacin reduced the inflammatory response, but had only minor effects on DC migration, whereas diflorasone diacetate reduced both inflammatory reaction and DC migration. Thus, NSAIDs may differ in their inhibitory action in immunological inflammation.

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Citations

Aug 15, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·S SchumacherW Bäumer
Nov 6, 2012·Progress in Lipid Research·Alexandra C Kendall, Anna Nicolaou
Mar 30, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Barbara RolandoAlberto Gasco
Mar 18, 2008·Experimental Dermatology·Christian LassStefan F Martin
Dec 5, 2008·Experimental Dermatology·Arthur KammeyerMarcel B M Teunissen
Jul 24, 2008·Experimental Dermatology·Kristine RossbachWolfgang Bäumer
Mar 9, 2010·Journal of Biomaterials Applications·K FeserF W Bach
May 31, 2019·International Journal of Molecular Sciences·Chan-Hee YuOk-Nam Bae

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