PMID: 9442367Jan 27, 1998Paper

Non-steroidal anti-inflammatory drug-induced renal failure: a brief review of the role of cyclo-oxygenase isoforms

Current Opinion in Nephrology and Hypertension
C M VenturiniP Needleman

Abstract

Non-steroidal anti-inflammatory drugs are efficacious treatments for rheumatoid arthritis and osteoarthritis. However, an adverse effect of treatment with non-steroidal anti-inflammatory drugs is acute renal failure, particularly in a subset of patients that are in a state of effective volume depletion. The frequency of this side-effect in the general treated population is not known, but is probably less than 1% per year. Non-steroidal anti-inflammatory drugs act by inhibiting the synthesis of prostaglandins, which are important mediators of renal function. In the volume-depleted state prostaglandins may counter the vasoconstriction associated with the activation of the renin-angiotensin system. Cyclooxygenase is the rate-limiting enzyme involved in the synthesis of prostaglandins. Cyclooxygenase exists in two forms: a constitutive form (cyclooxygenase-1) and an inducible form (cyclooxygenase-2), which is associated with inflammation. Non-steroidal anti-inflammatory drugs are non-specific inhibitors of both forms of cyclooxygenase. New data are emerging regarding the role of cyclooxygenase-2 in the control of renal function. In normal rat and dog kidney, cyclooxygenase-2 is sparsely expressed in the macula densa, but expression...Continue Reading

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Citations

Jun 16, 2005·American Journal of Physiology. Renal Physiology·Sarah Knight, Edward J Johns
Dec 3, 2009·Biological & Pharmaceutical Bulletin·Xiao-ping ZhouShao-chun Qu
May 9, 2007·The Journal of Veterinary Medical Science·Tatsuya NaritaShigeo Hara
Nov 11, 1999·Clinical Cardiology·J M Wilson, J J Ferguson
Oct 8, 2005·The Journal of Veterinary Medical Science·Tatsuya NaritaShigeo Hara
Jan 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Patricia Van der NiepenDierik Verbeelen
Mar 31, 2011·Renal Failure·Kamal HassanShadi Hassan
Nov 23, 2006·Neurosurgical Focus·Joseph C MaroonNathan A Ross
Jul 5, 2006·American Journal of Veterinary Research·Tatsuya NaritaShigeo Hara
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Apr 20, 2001·European Journal of Medicinal Chemistry·G Dannhardt, W Kiefer
Mar 29, 2002·Kidney International·Kanwar Nasir M KhanTimothy J Maziasz
Mar 13, 2003·Chemical Reviews·Rajni GargCorwin Hansch
Sep 3, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Olivier PhanMichel Burnier
May 8, 1999·Medicinal Research Reviews·J J TalleyK Seibert
Sep 15, 2005·Chemical Reviews·A S Michaelidou, D Hadjipavlou-Litina

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