Non-steroidal anti-inflammatory drugs among chronic kidney disease patients: an epidemiological study

The Journal of the Egyptian Public Health Association
Samar Abd ElHafeezSunny Sallam

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided among chronic kidney disease (CKD) patients. Till now, limited data are available on NSAID use in Egypt, and we aimed to study the prevalence and pattern of NSAID use among CKD patients. A cross-sectional study was done among 350 CKD adult patients presented to the Main Alexandria University Hospital. Those with end-stage renal disease and diagnosed with acute renal injury and pregnant women were excluded. Demographic and clinical data were collected by interviewing eligible patients. Data about the pattern, history of drug-drug interactions, and knowledge about the NSAID side effects were also gathered. Of the enrolled patients, 57.1% were hypertensive, 46% were diabetics, 28% had osteoarthritis, and 18.3% had cardiovascular disease. CKD stages were 3.7%, 40.3%, and 56% in stages 2, 3, and 4, respectively. Almost two thirds (65.7%) were NSAID users. Among them, 82.6% were regular users. Headache was the most reported (68.7%) reason of use. The use of drugs which may have drug-drug interaction with the NSAIDs (as diuretics or renin-angiotensin-aldosterone system inhibitors) was reported in 36%. In multiple logistic regression, the odds of NSAID use decreased by 4%...Continue Reading

References

Dec 12, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·C M HughesG F Fleming
Nov 2, 2004·BMJ : British Medical Journal·Keith HawtonKenneth Simpson
Jan 29, 2005·British Journal of Clinical Pharmacology·Katarzyna K Loboz, Gillian M Shenfield
Jul 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Joseph A VassalottiAndrew S Levey
Apr 30, 2008·Journal of General Internal Medicine·Michael B RothbergGregory L Braden
Jun 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Mark A Perazella
Jun 29, 2010·Pharmacoepidemiology and Drug Safety·Hsin-Wei KuoChun-Yuh Yang
May 13, 2011·Journal of Renal Care·Theodora KafkiaJohn Sedgewick
Sep 14, 2011·Annals of Family Medicine·Laura PlantingaUNKNOWN CDC CKD Surveillance Team
Feb 13, 2014·Seminars in Dialysis·Sara N DavisonFrank Brennan
Jul 2, 2014·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Sally HullMuhammad Magdi Yaqoob
Apr 20, 2016·International Journal of Clinical Pharmacy·Willem P MeuwesenMarike Cockeran
Sep 30, 2016·Journal of Nephrology·Zbigniew HeleniakAlicja Dębska-Ślizień
Jul 21, 2010·Pharmaceuticals·Walter H Hörl
Aug 16, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Min ZhanUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators

❮ Previous
Next ❯

Citations

May 8, 2020·Journal of Clinical Medicine·Maria Antonietta BarbieriVincenzo Arcoraci
Aug 22, 2020·Journal of Pain Research·Kok Yuen HoErnest Choy
Oct 26, 2021·Frontiers in Pharmacology·Vincenzo ArcoraciUNKNOWN REPOSI investigators

❮ Previous
Next ❯

Software Mentioned

info
Epi

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.