Non-steroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use

The Cochrane Database of Systematic Reviews
D A GrimesK F Schulz

Abstract

Heavy bleeding and pain are the most common reasons why women discontinue IUDs. Non-steroidal anti-inflammatory drugs, which inhibit prostaglandin synthesis, have been shown to be effective in reducing menstrual bleeding and pain in women without IUDs. This review summarizes all randomized controlled trials studying use of nonsteroidal anti-inflammatory drugs for treatment of bleeding or pain associated with IUD use. Trials of prophylactic use of these drugs around the time of IUD insertion were also included. We performed searches of PubMed, CENTRAL, POPLINE, EMBASE, LILACS, and CINAHL for relevant trials. We also wrote to the authors of all trials identified to seek other published or unpublished trials. We included all randomized controlled trials in any language that tested one or more nonsteroidal anti-inflammatory drugs for treatment or prevention of bleeding or pain associated with IUD insertion or use. Two authors independently abstracted data from relevant trials, and we entered data into RevMan for analysis. We found 15 trials from 10 countries; the total number of participants was 2702. Nonsteroidal anti-inflammatory drugs (naproxen, suprofen, mefenamic acid, ibuprofen, indomethacin, flufenamic acid, alclofenac, and ...Continue Reading

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Citations

May 15, 2013·Human Reproduction Update·K Gemzell-DanielssonL Bahamondes
Sep 1, 2007·BMJ : British Medical Journal·Sally B Rose
Mar 18, 2011·The Cochrane Database of Systematic Reviews·Rachel MollHenry J McQuay
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Oct 21, 2015·Perspectives on Sexual and Reproductive Health·Carolyn SufrinAndrea Jackson
Oct 25, 2017·Obstetrics and Gynecology·UNKNOWN Committee on Practice Bulletins-Gynecology, Long-Acting Reversible Contraception Work Group
May 6, 2019·Journal of Gynecology Obstetrics and Human Reproduction·Nathalie Chabbert-BuffetBernard Hédon

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