Non-suppressive regulatory T cell subset expansion in pulmonary arterial hypertension

Heart and Vessels
Yoshiharu SadaYasuki Kihara

Abstract

Regulatory T cells (Tregs) have been reported to play a pivotal role in the vascular remodeling of pulmonary arterial hypertension (PAH). Recent studies have revealed that Tregs are heterogeneous and can be characterized by three phenotypically and functionally different subsets. In this study, we investigated the roles of Treg subsets in the pathogenesis of PAH in eight patients with PAH and 14 healthy controls. Tregs and their subsets in peripheral blood samples were analyzed by flow cytometry. Treg subsets were defined as CD4(+)CD45RA(+)FoxP3(low) resting Tregs (rTregs), CD4(+)CD45RA(-)FoxP3(high) activated Tregs (aTregs), and CD4(+)CD45RA(-)FoxP3(low) non-suppressive Tregs (non-Tregs). The proportion of Tregs among CD4(+) T cells was significantly higher in PAH patients than in controls (6.54 ± 1.10 vs. 3.81 ± 0.28 %, p < 0.05). Of the three subsets, the proportion of non-Tregs was significantly elevated in PAH patients compared with controls (4.06 ± 0.40 vs. 2.79 ± 0.14 %, p < 0.01), whereas those of rTregs and aTregs were not different between the two groups. Moreover, the expression levels of cytotoxic T lymphocyte antigen 4, a functional cell surface molecule, in aTregs (p < 0.05) and non-Tregs (p < 0.05) were significa...Continue Reading

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Citations

Feb 19, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Levi D MastonLaura V Gonzalez Bosc
Oct 17, 2017·Acta Biochimica Et Biophysica Sinica·Cheng LiShangjie Wu
Mar 17, 2018·Circulation Research·Rasa TamosiunieneMark R Nicolls
Apr 4, 2021·International Journal of Molecular Sciences·Baptiste GouyouMarcus Franz
Aug 28, 2021·Journal of Clinical Medicine·Michał TomaszewskiEwelina Grywalska

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