Non-syndromic orofacial clefts in Southern Italy: pattern analysis according to gender, history of maternal smoking, folic acid intake and familial diabetes

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Francesco CarinciFernando Gombos

Abstract

Genetic studies have demonstrated that non-syndromic clefts of the lip, alveolus and palate have an heterogeneous genetic background, and that environmental factors contribute to the onset of this malformation. Therefore studies on different and homogeneous populations can be useful in detecting potentially related environmental and genetic factors. The aim of the present study was to evaluate whether gender, folic acid intake, family history of diabetes and/or smoking during pregnancy were associated with a specific type of cleft in a group of patients affected by non-syndromic clefts, collected from Southern Italy. Data from one hundred and twenty-six patients were evaluated retrospectively. Each cleft was described as composed by separate antomical entities such as lip, alveolus, primary and secondary palate. None had an isolated alveolar cleft and this was used as internal control. Pattern analysis was used to detect differences in the frequencies of any possible combination of 7 types of clefting stratified according to the studied variables. Data were analysed by comparing observed proportions. Isolated cleft palate as well as right-sided clefts of lip, alveolus and palate were more frequent in females (p = 0.0014 and 0.0...Continue Reading

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Citations

Nov 26, 2009·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Alexandra I HolstUrsula Hirschfelder
Apr 11, 2014·Journal of Medical Case Reports·Mariano LacarbonaraMario Capogreco
Sep 3, 2010·African Health Sciences·V W Omo-AghojaA Onowhakpor
Jul 19, 2011·The British Journal of Oral & Maxillofacial Surgery·Richard Aurélien RakotoarisonAhmed Feki
May 6, 2008·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Ranko MladinaZeljko Orihovac
Dec 30, 2015·African Journal of Paediatric Surgery : AJPS·Morteza NoorollahianGholam Reza Khademi
Sep 26, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Carlos F SantosAlceu S Trindade
Mar 20, 2018·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·K SarmientoI Zarante
Aug 28, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Teresa KruseBert Braumann

Related Concepts

Cleft Lip
Cleft Palate, Isolated
Diabetes Mellitus
Family Health Status
Folic Acid Deficiency
Prenatal Exposure Delayed Effects
Retrospective Studies
Cigar smoker
Incidence Studies

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