PMID: 6966262Apr 15, 1980Paper

Non-T-cell-mediated cytotoxicity in MSV tumor-bearing mice. III. Macrophage-mediated cytotoxicity against autochthonous MSV tumor-isolated target cells

International Journal of Cancer. Journal International Du Cancer
S Becker, S Haskill

Abstract

Cytotoxic macrophages have been isolated from Moloney sarcoma virus (MSV) tumors induced in uncompromised, immunosuppressed and athymic nude mice. Macrophages from compromised mice were at least as active as those from uncompromised mice when tested against the autochthonous MSV target cells. Although both cytolytic and cytostatic activity could be demonstrated with all tumor-derived macrophages, cytostatic and cytolytic effects could be distinguished from each other only at high effector target-cell ratios. A variety of target cells were compared for sensitivity to the various tumor-associated macrophages. The autochthonous virus-infected MSV-target cells appeared to be more sensitive to the macrophage effects than fastgrowing, established cell lines. Normal embryo fibroblasts were only slightly affected. Peritoneal exudate cells from tumor-bearers were much less active than either the tumor-isolated macrophages or bone-marrow culture-derived macrophages. Both were more active than control peritoneal cells. Although no quantitative or qualitative differences in macrophage activity could be detected in mice with regressing lesions and immuno-compromised mice with progressing lesions, the ratio of macrophages to "sarcoma" cells ...Continue Reading

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Citations

Jan 1, 1982·Cancer Metastasis Reviews·E F WheelockG A Truitt
Jan 1, 1983·Cancer Investigation·J D IglehartD P Bolognesi
Feb 15, 1981·International Journal of Cancer. Journal International Du Cancer·S Becker, S Haskill
Apr 15, 1980·International Journal of Cancer. Journal International Du Cancer·S Becker, S Haskill
Oct 15, 1984·International Journal of Cancer. Journal International Du Cancer·A GuariniA Mantovani
Nov 15, 1982·International Journal of Cancer. Journal International Du Cancer·E V GenovesiJ J Collins
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koen SchepersTon N M Schumacher
Aug 5, 1986·Biochimica Et Biophysica Acta·W H McBride

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