Non-targeted, high resolution mass spectrometry strategy for simultaneous monitoring of xenobiotics and endogenous compounds in green sea turtles on the Great Barrier Reef

The Science of the Total Environment
Amy L HeffernanMaria J Gómez-Ramos

Abstract

Chemical contamination poses a threat to ecosystem, biota and human health, and identifying these hazards is a complex challenge. Traditional hazard identification relies on a priori-defined targets of limited chemical scope, and is generally inappropriate for exploratory studies such as explaining toxicological effects in environmental systems. Here we present a non-target high resolution mass spectrometry environmental monitoring study with multivariate statistical analysis to simultaneously detect biomarkers of exposure (e.g. xenobiotics) and biomarkers of effect in whole turtle blood. Borrowing the concept from clinical chemistry, a case-control sampling approach was used to investigate the potential influence of xenobiotics of anthropogenic origin on free-ranging green sea turtles (Chelonia mydas) from a remote, offshore 'control' site; and two coastal 'case' sites influenced by urban/industrial and agricultural activities, respectively, on the Great Barrier Reef in North Queensland, Australia. Multiple biomarkers of exposure, including sulfonic acids (n=9), a carbamate insecticide metabolite, and other industrial chemicals; and five biomarkers of effect (lipid peroxidation products), were detected in case sites. Additiona...Continue Reading

Citations

Dec 13, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Julian L Griffin
Oct 21, 2020·The Science of the Total Environment·Kimberly A FinlaysonJason P van de Merwe
May 10, 2021·Environment International·Caroline Simonnet-LapradeGaud Dervilly
Sep 16, 2020·The Science of the Total Environment·Colette R ThomasIan Bell
Mar 17, 2019·Journal of the American Society for Mass Spectrometry·Annie von Eyken, Stéphane Bayen
Dec 1, 2021·Environmental Science & Technology·Aikebaier RenaguliBernard S Crimmins

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