Non-traditional metabolic pathways of adrenal steroids.

Reviews in Endocrine & Metabolic Disorders
Richard J Auchus

Abstract

Metabolic pathways are reconstructed from biochemical evidence to conceptualize the predominant route to important biomolecules. Pathways have heuristic value in their capacity to explain the metabolic derangements in genetic diseases of enzyme deficiencies and during pharmacologic inhibition of these enzymes. Implicit in the description of these pathways is the potential existence of alternate routes, variable order of reactions, and the inevitable by-products generated by incomplete efficiencies and competing enzymes. This chapter will consider alternate fates encountered by steroid hormone precursors in the adrenal gland, the variables influencing flux through these secondary pathways, and the significance of these diversions in health and disease.

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Citations

Nov 6, 2013·Steroids·Tea Lanišnik Rižner, Trevor M Penning
Jul 31, 2010·International Journal of Pediatric Endocrinology·Selma Feldman Witchel, Ricardo Azziz
Dec 2, 2009·Journal of Pediatric Nursing·Carol Van Ryzin
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Apr 9, 2014·Annals of Clinical Biochemistry·John W Honour
Apr 27, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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