PMID: 9173695Feb 1, 1997Paper

Non-transmural anterior wall infarct: changes in myocardial energy metabolism in remaining vital myocardium

Zeitschrift für Kardiologie
D MokaH Schicha

Abstract

To characterize energy metabolism in vivo after nontransmural anterior myocardial infarction, patients (group A, n = 19) with a stenosis of left anterior descending artery (LAD) and anterior wall hypokinesia by levocardiography were examined by phosphorus magnetic resonance spectroscopy (MRS). Spectra were compared to those of healthy volunteers (n = 15). The volume of interest was placed into the anterior myocardial wall by magnetic resonance imaging. Phosphorus spectra were recorded under optimal antiischemic medication. To separate the influence of coronary stenosis from that of the ischemic insult, additional patients (group B, n = 4) with LAD-stenosis but without left ventricular dysfunction were examined. The effect of antiischemic medication on the phosphorus spectra was evaluated in patient group C (n = 4), who had the same clinical features as group A. In these patients, MRS was first performed without antiischemic medication (washout period > one day) and then repeated during intravenous application of glyceroltrinitrate (GTN). Mean PCr/ATP-ratio was significantly lower in group A patients (1.24 +/- 0.18) than in healthy volunteers (1.74 +/- 0.23; p < 0.01 unpaired t-test). Patients with normal left ventricular functi...Continue Reading

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