Non-tuberculous mycobacteria in HIV-negative patients with pulmonary disease in Lisbon, Portugal

Scandinavian Journal of Infectious Diseases
António AmorimEdna Pereira

Abstract

Non-tuberculous mycobacteria (NTM) are responsible for an increase in mycobacterial disease in many developed countries. However the epidemiology, especially in patients without HIV infection, remains difficult to determine. We studied a convenience sample of 5497 HIV-negative patients receiving care at our pneumology centres. Among 510 patients with mycobacterial isolates, NTM were demonstrated in 58, all showing signs of lung disease. The mycobacteria isolated were M. intracellulare (n = 9, 15.5%), M. fortuitum (n = 8, 13.8%), M. gordonae (n = 7, 12.1%), M. kansasii (n = 6, 10.3%), M. chelonae (n = 5, 8.6%), M. avium (n = 4, 6.9%), M. abscessus (n = 3, 5.2%), M. peregrinum (n = 3, 5.2%), M. triplex (n = 3, 5.2%), M. spp. (n = 3, 5.2%), M. szulgai (n = 3, 5.2%), M. mucogenicum (n = 2, 3.4%), M. lentiflavum (n = 1, 1.7%) and M. simiae (n = 1, 1.7%). The present high percentage of NTM strains among mycobacterial isolates (approximately 11%), suggests the emergence of NTM infections as a public health problem. Larger, multicentre and multiregional studies or mandatory reporting will be required to better understand the changing epidemiology of NTM in patients with lung disease.

References

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Citations

Apr 26, 2013·Foodborne Pathogens and Disease·Alena LorencovaMichal Slany
Jan 24, 2014·BioMed Research International·Zofia BakułaTomasz Jagielski
Feb 8, 2014·BMC Infectious Diseases·Marieke J van der WerfVibeke Ostergaard Thomsen
Nov 13, 2015·Tuberculosis·Daniela Nunes-CostaNuno Empadinhas
Jun 5, 2012·Research in Veterinary Science·Valentina V EbaniEnrico Tortoli
Dec 6, 2011·Diagnostic Microbiology and Infectious Disease·Chih-Cheng LaiPo-Ren Hsueh
Mar 2, 2016·International Journal of Mycobacteriology·Carlos Eduardo Dias CamposJesus Pais Ramos
Oct 22, 2011·Diagnostic Microbiology and Infectious Disease·Chung-Yu ChenPo-Ren Hsueh
Feb 14, 2015·Clinics in Chest Medicine·D Rebecca Prevots, Theodore K Marras
Jul 16, 2015·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Hans DabóAdelina Amorim

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