Non-Tuberculous Mycobacteria Interference with BCG-Current Controversies and Future Directions

Vaccines
Deepshikha VermaDiane J Ordway

Abstract

The global tuberculosis (TB) epidemic caused by the bacterial pathogen Mycobacterium tuberculosis (M.tb) continues unabated. The Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination is widely utilized worldwide to protect against infection with M.tb. BCG vaccine protection against TB has had widely varying results for reasons that are not well understood. BCG vaccine interference by non-tuberculosis (NTM) mycobacterial species has been implicated as the potential cause of reduced BCG vaccine efficacy against M.tb. Ongoing efforts to develop new vaccines for TB requires a thorough understanding of the effect of NTM exposure on BCG vaccine efficacy, which may ultimately be a critical determinant of success. We reviewed the conflicting reports on whether NTM interferes with the BCG vaccine, potential explanations to help resolve the controversy, and strategies for developing better animal models. Further studies are needed to longitudinally track the effects of NTM exposure on BCG vaccine-induced host-protective anti-TB immunity.

References

Jul 1, 1989·Journal of Clinical Immunology·N LahatT C Iancu
Apr 4, 2000·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E PadillaV Ausina
Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L S Young, L E Bermudez
Jan 17, 2004·Clinical Microbiology Reviews·Todd P PrimmJoseph O Falkinham
Mar 10, 2004·Springer Seminars in Immunopathology·G A W RookL Rosa Brunet
Mar 19, 2004·Immunology·M Salomé GomesRui Appelberg
May 24, 2005·Infection and Immunity·Manuela FlóridoRui Appelberg
Sep 6, 2005·The Surgical Clinics of North America·David I Soybel
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diane OrdwayIan M Orme
Apr 11, 2008·Clinical Microbiology Reviews·L Beth Gadkowski, Jason E Stout
Jun 17, 2008·American Journal of Respiratory Cell and Molecular Biology·Ashwin S Dharmadhikari, Edward A Nardell
Oct 9, 2009·COPD·Rebecca E Oberley-DeeganJames D Crapo
Jan 19, 2010·American Journal of Respiratory Cell and Molecular Biology·Edward D ChanDiane J Ordway
Feb 2, 2010·Emerging Infectious Diseases·Chih Cheng LaiPo Ren Hsueh
Apr 10, 2010·Lung·Emmet E McGrathPaul B Anderson
May 29, 2010·American Journal of Respiratory and Critical Care Medicine·Kevin L WinthropKatrina Hedberg
Jun 1, 2010·Journal of Immune Based Therapies and Vaccines·Rajpal S KashyapHatim F Daginawala
Oct 22, 2011·Diagnostic Microbiology and Infectious Disease·Chung-Yu ChenPo-Ren Hsueh
Jun 20, 2012·Statistics in Medicine·Nicholas A Christakis, James H Fowler
Jul 17, 2012·Diagnostic Microbiology and Infectious Disease·Erin EpsonKevin L Winthrop
Nov 13, 2012·American Journal of Respiratory and Critical Care Medicine·Marinka KartalijaEdward D Chan
Feb 16, 2013·Internal Medicine·Yu KuraharaKatsuhiro Suzuki
Apr 20, 2013·The European Respiratory Journal·Wouter HoefslootUNKNOWN Nontuberculous Mycobacteria Network European Trials Group
Oct 26, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ching LanAlice May-Kuen Wong
Jan 31, 2015·Journal of the American Veterinary Medical Association·Robert V BlairCherie M Pucheu-Haston
Feb 14, 2015·Clinics in Chest Medicine·Jennifer R HondaEdward D Chan
Feb 14, 2015·Clinics in Chest Medicine·D Rebecca Prevots, Theodore K Marras
Aug 26, 2015·Antimicrobial Agents and Chemotherapy·Andrés Obregón-HenaoDiane J Ordway
Mar 25, 2016·Expert Review of Vaccines·Helen McShane, Tamara Davenne
Mar 30, 2016·Current Environmental Health Reports·Joseph O Falkinham
Apr 14, 2016·Nature Communications·Helen A FletcherHelen McShane
Jan 15, 2017·Microbiology Spectrum·Susanna Brighenti, Diane J Ordway
Apr 13, 2017·Indian Journal of Orthopaedics·Manit K GundavdaRamesh B Deshpande
Apr 30, 2017·Angewandte Chemie·Werner Uhl, Sumati Panicker

❮ Previous
Next ❯

Citations

Mar 14, 2021·Immunological Reviews·Deepshikha VermaDiane J Ordway
May 7, 2021·Immunological Reviews·Asma AhmedAnnapurna Vyakarnam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.