Non-tumor-Associated Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis in Chinese Girls With Positive Anti-thyroid Antibodies

Journal of Child Neurology
Wenjuan GuanYanjie Jia

Abstract

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a new category of autoimmune encephalitis associated with anti-NMDA receptor antibodies. The disease was first described in 2007, and it predominantly affects young women with or without ovarian teratomas. Most patients typically present with seizures, a decreased consciousness level, dyskinesia, autonomic dysfunction, and psychiatric symptoms. The presence of anti-thyroid antibodies in non-tumor-associated anti-NMDA receptor encephalitis was first described in 2010. Additionally, anti-thyroid antibodies were found in teratoma-associated anti-NMDA receptor encephalitis. We report the cases of 3 Chinese girls with non-tumor-associated anti-NMDA receptor encephalitis with positive anti-thyroid antibodies. We followed up the details of their titers and suggest that anti-thyroid antibodies were an indicator of autoimmune predisposition in the development of non-tumor-associated anti-NMDA receptor encephalitis.

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Citations

Oct 29, 2015·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Shelly Scheer, Rita Marie John
May 8, 2016·The American Journal of Medicine·Joseph A ClaraKellee L Oller
Jul 15, 2015·Journal of Epilepsy Research·Jiyoung KimDae Soo Jung
Mar 1, 2016·Dementia and Neurocognitive Disorders·Yoori JungEun-Joo Kim
Jul 3, 2019·Parkinsonism & Related Disorders·Victor S C Fung

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