Non-uniform central airways ventilation model based on vascular segmentation

Computers in Biology and Medicine
G IbrahimS V Hainsworth

Abstract

Improvements in the understanding of the physiology of the central airways require an appropriate representation of the non-uniform ventilation at its terminal branches. This paper proposes a new technique for estimating the non-uniform ventilation at the terminal branches by modelling the volume change of their distal peripheral airways, based on vascular segmentation. The vascular tree is used for sectioning the dynamic CT-based 3D volume of the lung at 11 time points over the breathing cycle of a research animal. Based on the mechanical coupling between the vascular tree and the remaining lung tissues, the volume change of each individual lung segment over the breathing cycle was used to estimate the non-uniform ventilation of its associated terminal branch. The 3D lung sectioning technique was validated on an airway cast model of the same animal pruned to represent the truncated dynamic CT based airway geometry. The results showed that the 3D lung sectioning technique was able to estimate the volume of the missing peripheral airways within a tolerance of 2%. In addition, the time-varying non-uniform ventilation distribution predicted by the proposed sectioning technique was validated against CT measurements of lobar ventila...Continue Reading

References

Mar 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S J Lai-Fook
Dec 1, 1974·Journal of Applied Physiology·J J BenjaminS Permutt
Oct 1, 1973·The Anatomical Record·R F PhalenD J Velasquez
Jan 1, 1980·Annual Review of Physiology·B H Culver, J Butler
Nov 15, 2002·Journal of Anatomy·Alison A Hislop
Dec 22, 2007·Medical Engineering & Physics·J W De BackerW De Backer
Jan 7, 2010·International Journal of Biomedical Imaging·Hidenori ShikataMilan Sonka
May 21, 2010·Journal of Biomechanics·Youbing YinChing-Long Lin
Nov 19, 2010·Radiology·Jan W De BackerWilfried De Backer
Feb 11, 2011·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Andrew R LambertChing-Long Lin
Jun 22, 2013·Experimental Lung Research·Richard E JacobJames P Carson
Jun 25, 2013·Journal of Computational Physics·Youbing YinChing-Long Lin
Jun 27, 2013·PloS One·Richard E JacobDaniel R Einstein

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Citations

Nov 26, 2015·Journal of Biomechanical Engineering·G IbrahimS V Hainsworth

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