Non-Vaccine-Type Human Papillomavirus Prevalence After Vaccine Introduction: No Evidence for Type Replacement but Evidence for Cross-Protection

Sexually Transmitted Diseases
Mónica SaccucciJessica A Kahn

Abstract

We examined non-vaccine-type human papillomavirus (HPV) prevalence in a community before and during the first 8 years after vaccine introduction, to assess for (1) type replacement with any non-vaccine-type HPV and (2) cross-protection with non-vaccine types genetically related to vaccine-type HPV. Sexually experienced 13- to- 26-year-old women were recruited for 3 cross-sectional studies from 2006 to 2014 (N = 1180). Outcome variables were as follows: (1) prevalence of at least 1 of 32 anogenital non-vaccine-type HPVs and (2) prevalence of at least 1 HPV type genetically related to HPV-16 and HPV-18. We determined changes in proportions of non-vaccine-type HPV prevalence across the study waves using logistic regression with propensity score inverse probability weighting. Vaccine initiation rates increased from 0% to 71.3%. Logistic regression demonstrated that from 2006 to 2014, there was no increase in non-vaccine-type HPV among vaccinated women (adjusted odds ratio [AOR], 1.02; 95% confidence interval [CI], 0.73-1.42), but an increase among unvaccinated women (AOR, 1.88; 95% CI, 1.16-3.04). Conversely, there was a decrease in types genetically related to HPV-16 among vaccinated (AOR, 0.57; 95% CI, 0.38-0.88) but not unvaccin...Continue Reading

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Citations

Jan 12, 2019·Human Vaccines & Immunotherapeutics·Courtney CovertJessica A Kahn
Sep 27, 2018·Scientific Reports·Ho-Lan PengHongyu Miao
Sep 24, 2019·Human Vaccines & Immunotherapeutics·Chantal SauvageauVladimir Gilca
Apr 9, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irene ManJohannes A Bogaards
Jul 11, 2018·International Journal of Environmental Research and Public Health·Emilien JeannotPatrick Petignat
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Neerja BhatlaRengaswamy Sankaranarayanan

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