Non-Verbal Episodic Memory Deficits in Primary Progressive Aphasias are Highly Predictive of Underlying Amyloid Pathology

Journal of Alzheimer's Disease : JAD
Siddharth RamananMichael Hornberger

Abstract

Diagnostic distinction of primary progressive aphasias (PPA) remains challenging, in particular for the logopenic (lvPPA) and nonfluent/agrammatic (naPPA) variants. Recent findings highlight that episodic memory deficits appear to discriminate these PPA variants from each other, as only lvPPA perform poorly on these tasks while having underlying amyloid pathology similar to that seen in amnestic dementias like Alzheimer's disease (AD). Most memory tests are, however, language based and thus potentially confounded by the prevalent language deficits in PPA. The current study investigated this issue across PPA variants by contrasting verbal and non-verbal episodic memory measures while controlling for their performance on a language subtest of a general cognitive screen. A total of 203 participants were included (25 lvPPA; 29 naPPA; 59 AD; 90 controls) and underwent extensive verbal and non-verbal episodic memory testing, with a subset of patients (n = 45) with confirmed amyloid profiles as assessed by Pittsburgh Compound B and PET. The most powerful discriminator between naPPA and lvPPA patients was a non-verbal recall measure (Rey Complex Figure delayed recall), with 81% of PPA patients classified correctly at presentation. Impo...Continue Reading

References

Oct 1, 1994·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·O PiguetP F Bladin
Mar 3, 2004·Annals of Neurology·Maria Luisa Gorno-TempiniBruce L Miller
Sep 16, 2006·International Journal of Geriatric Psychiatry·Eneida MioshiJohn R Hodges
Oct 12, 2007·Brain : a Journal of Neurology·Kerryn E PikeChristopher C Rowe
Oct 20, 2007·Lancet Neurology·John R Hodges, Karalyn Patterson
Jul 18, 2008·Neurology·M L Gorno-TempiniB L Miller
Jun 9, 2009·NeuroImage·Stephen M WilsonMaria Luisa Gorno-Tempini
Jun 15, 2010·Brain : a Journal of Neurology·Stephen M WilsonMaria Luisa Gorno-Tempini
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Jul 31, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Samrah AhmedPeter Garrard
Oct 4, 2012·Journal of Speech, Language, and Hearing Research : JSLHR·Karen CrootJohn R Hodges
Mar 8, 2013·Dementia and Geriatric Cognitive Disorders·Sharon SavageJohn R Hodges
Dec 11, 2013·Journal of Alzheimer's Disease : JAD·Emma C FlanaganMichael Hornberger
Apr 1, 2008·Dementia & Neuropsychologia·Helen J WearJohn R Hodges

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Citations

Oct 19, 2017·Journal of the International Neuropsychological Society : JINS·Christa L WatsonMaria Luisa Gorno-Tempini
Jun 4, 2019·Journal of Alzheimer's Disease : JAD·Mario F MendezMegan Laffey
Nov 9, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Nancy MaserejianFeng Gao
Oct 30, 2019·Journal of the International Neuropsychological Society : JINS·Vidyulata KamathGrace-Anna Chaney
Jun 19, 2019·Learning & Memory·Siddharth RamananMuireann Irish
Jan 9, 2021·Journal of Neurology·David FoxeOlivier Piguet
Dec 18, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Lulu LiuMuireann Irish
Nov 25, 2018·Neurobiology of Aging·Brian B AvantsUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 1, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David FoxeOlivier Piguet
Apr 10, 2021·Applied Neuropsychology. Adult·Ismael Luis CalandriRicardo Francisco Allegri
Jun 22, 2018·Neuroscience and Biobehavioral Reviews·Willem S EikelboomRoy P C Kessels
Jul 27, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·David FoxeOlivier Piguet
Dec 11, 2021·The European Journal of Neuroscience·David FoxeOlivier Piguet

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