PMID: 7539329Jan 1, 1995Paper

Non-viral approaches to gene therapy

British Medical Bulletin
J P Schofield, C T Caskey

Abstract

There have been rapid advances in the development of non-viral techniques for gene transfer. Although viruses are highly evolved to infect mammalian cells, they have several limitations. The general theme is to mimic the advantageous components of viral systems whilst separating them from their limiting functions. The systems described here are broadly divided into true non-viral techniques and viral-assisted technologies. The merits and limitations of each method are presented, and examples of their application to current developments in gene therapy are discussed. At present no preferred technique has emerged as a clear favourite for non-viral delivery. Further refinement of the technology with particular emphasis on achieving long-term gene expression is required before initiating clinical trials of non-viral gene delivery.

Citations

Jun 2, 2001·Human Gene Therapy·C G LeeM M Gottesman
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoichi OikawaTakao Saruta
Feb 2, 2006·Fundamental & Clinical Pharmacology·Anne-Sophie ArnoldJean-Pierre Gies
Sep 22, 1998·Nature Biotechnology·H Aihara, J Miyazaki
Feb 1, 2007·Journal of Biomedical Materials Research. Part a·Ronny MartienAndreas Bernkop-Schnürch
Sep 23, 2010·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Faris Q AlenziRichard K H Wyse
Oct 1, 1995·Brain Pathology·C M KrammX O Breakefield
Sep 1, 1996·Cancer Metastasis Reviews·J Zhang, S J Russell
Aug 1, 1996·Therapeutic Drug Monitoring·M K Brenner
Jun 13, 2002·Clinical and Experimental Pharmacology & Physiology·Naoki OhmiyaTetsuo Hayakawa
Mar 1, 1997·Experimental Neurology·H K RaymonF H Gage
May 23, 2001·Neuromuscular Disorders : NMD·E EspinosL Bernheim
Nov 13, 1998·Journal of Pharmaceutical Sciences·V LabhasetwarR J Levy

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Chemical Society Reviews
Xavier Salvatella, Ernest Giralt
European Journal of Drug Metabolism and Pharmacokinetics
E Beyssac
Journal of Tissue Engineering and Regenerative Medicine
Pawanbir Singh, David J Williams
Canadian Journal of Experimental Psychology = Revue Canadienne De Psychologie Expérimentale
Kristie R Dukewich, Raymond M Klein
© 2021 Meta ULC. All rights reserved