Non-viral in vivo immune gene therapy of cancer: combined strategies for treatment of systemic disease

Cancer Immunology, Immunotherapy : CII
Mark TangneyGerald C O'Sullivan

Abstract

Many patients with various types of cancers have already by the time of presentation, micrometastases in their tissues and are left after treatment in a minimal residual disease state [Am J Gastroenterol 95(12), 2000]. To prevent tumour recurrence these patients require a systemic based therapy, but current modalities are limited by toxicity or lack of efficacy. We have previously reported that immune reactivity to the primary tumour is an important regulator of micrometastases and determinant of prognosis. This suggests that recruitment of specific anti-tumour mechanisms within the primary tumour could be used advantageously for tumour control as either primary or neo-adjuvant treatments. Recently, we have focused on methods of stimulating immune eradication of solid tumours and minimal residual disease using gene therapy approaches. Gene therapy is now a realistic prospect and a number of delivery approaches have been explored, including the use of viral and non-viral vectors. Non-viral vectors have received significant attention since, in spite of their relative delivery inefficiency, they may be safer and have greater potential for delivery of larger genetic units. By in vivo electroporation of the primary tumour with plasm...Continue Reading

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Citations

Mar 28, 2007·Pharmaceutical Research·Verena Russ, Ernst Wagner
Apr 2, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sarfraz AhmadGerald C O'Sullivan
Sep 16, 2006·Human Gene Therapy·Loree C Heller, Richard Heller
Oct 11, 2012·Genetic Vaccines and Therapy·Sarfraz AhmadMark Tangney
Dec 22, 2010·Genetic Vaccines and Therapy·Sara A CollinsMark Tangney
Jan 1, 2010·Biotechnology & Genetic Engineering Reviews·F SousaJ A Queiroz
May 14, 2010·Postgraduate Medicine·Mark TangneyGerald C O'Sullivan
Apr 7, 2011·Bioengineered Bugs·Chwanrow K BabanMark Tangney
Dec 25, 2009·International Journal of Computer Assisted Radiology and Surgery·C BergmeirI Wolf
Nov 10, 2009·Expert Review of Anticancer Therapy·Mecker G MöllerGerald C O'Sullivan

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