Non-viral strategies for ocular gene delivery

Materials Science & Engineering. C, Materials for Biological Applications
Ana V OliveiraGabriela A Silva

Abstract

The success of gene therapy relies on efficient gene transfer and stable transgene expression. The in vivo efficiency is determined by the delivery vector, route of administration, therapeutic gene, and target cells. While some requirements are common to several strategies, others depend on the target disease and transgene product. Consequently, it is unlikely that a single system is suitable for all applications. This review examines current gene therapy strategies, focusing on non-viral approaches and the use of natural polymers with the eye, and particularly the retina, as their gene delivery target.

Citations

Mar 15, 2018·Current Opinion in Ophthalmology·Adam DeBusk, Mark L Moster
Sep 3, 2017·British Journal of Pharmacology·Sahar AwwadAlastair Lockwood
Feb 17, 2019·Journal of Tissue Engineering and Regenerative Medicine·Weiwei WangMingzhong Li
May 17, 2019·Expert Opinion on Drug Delivery·Francine Behar-Cohen
Apr 17, 2020·Fundamental & Clinical Pharmacology·Jinjin JiangJing Chen
Apr 15, 2020·Pharmaceutics·Fernando Alvarez-RiveraCarmen Alvarez-Lorenzo
Feb 26, 2019·International Journal of Retina and Vitreous·Parker E LudwigAdam C Janot
Jan 11, 2020·Frontiers in Immunology·Arden G Vanderwall, Erin D Milligan
Jul 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan L ParisSara Abalde-Cela
Feb 11, 2021·Pharmaceutics·Sanna KoponenSeppo Ylä-Herttuala
Feb 14, 2021·International Journal of Molecular Sciences·Elham PishavarSeeram Ramakrishna
Mar 9, 2021·Wiley Interdisciplinary Reviews. RNA·Mingyuan ZouJian Xu
Mar 31, 2021·Klinische Monatsblätter für Augenheilkunde·Stylianos MichalakisClaudia Priglinger
Apr 30, 2021·Carbohydrate Polymers·Xiaodan ZhangQiang Zhu
Jul 3, 2021·Pharmaceutics·Marcela Coelho Silva RibeiroArmando Silva-Cunha
Aug 11, 2021·Pharmaceutics·Elham RastegariYueh Chien
Sep 18, 2020·Current Pharmaceutical Design·Karthikeyan KesavanVal C Sheffield
Nov 3, 2021·Nanotechnology·Bahar NikforouzRezvan Mohammadinezhad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.