Nonadenomatous polyps at CT colonography: prevalence, size distribution, and detection rates

Radiology
Perry J PickhardtWilliam R Schindler

Abstract

To prospectively investigate with computed tomographic (CT) colonography the prevalence and size distribution of nonadenomatous polyps in asymptomatic adults and to compare the detection rates of adenomatous and nonadenomatous polyps. A total of 1233 asymptomatic adults (mean age, 57.8 years; 505 women, 728 men) underwent same-day CT colonography and optical colonoscopy procedures. CT colonoscopy studies were interpreted prospectively with a primary three-dimensional approach immediately before optical colonoscopy. Statistical analysis was performed with the chi(2) test. Size, prevalence, and by-polyp detection differences were compared between adenomatous and nonadenomatous polyps. Seven hundred fifty-six (57.7%) colorectal polyps identified at optical colonoscopy in 410 (33.3%) patients were nonadenomatous; of these lesions, 622 (82.3%) were diminutive (</=5 mm). Nonadenomatous polyps accounted for 622 (64.4%) of 966 diminutive lesions and 134 (39.9%) of 344 polyps 6 mm or larger (P <.001). The prevalence rate for nonadenomatous polyps was 8.8% (109 of 1233 patients) and 2.0% (25 of 1233 patients) at 6- and 10-mm thresholds, respectively. CT colonography by-polyp sensitivity for nonadenomatous lesions was 73.1% (98 of 134 pat...Continue Reading

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Apr 1, 2009·Nature Reviews. Clinical Oncology·Perry J Pickhardt
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