Abstract
To identify predictors of nonadherence to angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin II receptor blockers (ARBs) and to assess the association between nonadherence to ACEIs/ARBs and potentially avoidable hospitalizations (PAHs) among elderly high-risk patients with diabetes. Medicare Part D enrollees from six states who had diabetes and coexisting hypertension and/or renal disease, were aged 65 years or older, and who had filled at least one prescription for ACEIs/ARBs in the first 6 months of 2006 were included in this retrospective cohort study. The primary outcomes of interests were patient nonadherence to ACEI/ARB therapy, which was defined as a proportion of days covered (PDC) less than 0.8 and PAH for diabetes during the patient follow-up period (July 1, 2006, to March 31, 2007). A total of 599,141 patients (mean [+/-SD] age 75.6 +/-7.3 years, 66% women, 63% white, 15% black, and 9% Hispanic) were included. Among them, 46% were nonadherent to ACEI/ARB therapy and 6.3% had a PAH during the follow-up period. In multivariate logistic regressions, patients with diabetes and both hypertension and renal disease and patients with diabetes and renal disease only were 24% and 15% more likely, respectively,...Continue Reading
References
Nov 11, 1993·The New England Journal of Medicine·E J LewisR D Rohde
Mar 5, 1998·The New England Journal of Medicine·R O EstacioR W Schrier
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Dec 25, 2003·Diabetes Care·Carlos Arauz-PachecoUNKNOWN American Diabetes Association
Dec 25, 2003·Diabetes Care·Mark E MolitchUNKNOWN American Diabetes Association
Aug 31, 2004·Diabetes Care·Denys T Lau, David P Nau
Apr 27, 2005·The American Journal of Medicine·Richard R Rubin
Sep 13, 2005·Clinical Therapeutics·Robin P HertzMichael B Lustik
Sep 27, 2006·Archives of Internal Medicine·P Michael HoDavid J Magid
Jan 31, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andrew M PetersonMichael Nichol
Jul 19, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Helena W RodbardUNKNOWN AACE Diabetes Mellitus Clinical Practice Guidelines Task Force
Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanDavid R Matthews
Jan 6, 2009·Diabetes Care·UNKNOWN American Diabetes Association
Feb 10, 2009·BMC Health Services Research·Connie M TrinactyDennis Ross-Degnan
Citations
Apr 5, 2013·Drugs & Aging·Elisabeth Lilian Pia SattlerMatthew Perri
Feb 18, 2011·AIDS Patient Care and STDs·Kevin C HendersonJennifer J Kiser
Jan 21, 2016·International Journal of Cardiology·Ming LiuCheuk-Man Yu
Sep 14, 2014·Journal of the American Pharmacists Association : JAPhA·Janeen DuChaneIan Duncan
Jun 19, 2012·Journal of the American Geriatrics Society·Holly M HolmesJames S Goodwin
Feb 1, 2018·Journal of Managed Care & Specialty Pharmacy·Christina A SpiveyMarie Chisholm-Burns
Sep 6, 2019·British Journal of Clinical Pharmacology·Caroline A WalshKathleen E Bennett
Apr 3, 2020·Journal of Translational Medicine·Yue ZhangHongwei Li
Nov 30, 2021·PloS One·Justin G TrogdonJennifer L Lund