Nonadherence to antihypertensive medications is related to pill burden in apparent treatment-resistant hypertensive individuals

Journal of Hypertension
Alexander J LawsonIndranil Dasgupta

Abstract

Nonadherence to medication is present in at least 50% of patients with apparent treatment-resistant hypertension. We examined the factors associated with nonadherence as detected by a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based urine antihypertensive drug assay. All urine antihypertensive test results, carried out for uncontrolled hypertension (BP persistently >140/90 mmHg) between January 2015 and December 2016 at a single toxicology laboratory were analysed. Drugs detected were compared with the antihypertensive drugs prescribed. Patients were classified as adherent (all drugs detected), partially nonadherent (at least one prescribed drug detected) or completely nonadherent (no drugs detected). Demographic and clinical parameters were compared between the adherent and nonadherent groups. Binary logistic regression analysis was performed to determine association between nonadherence and demographic and clinical factors. Data on 300 patients from nine hypertension centres across the United Kingdom were analysed. The median age was 59 years, 47% women, 71% Caucasian, median clinic BP was 176/95 mmHg and the median number of antihypertensive drugs prescribed was four. One hundred and sixty-six (55%) were nonad...Continue Reading

References

Jul 1, 1990·Archives of Internal Medicine·J A CramerR H Mattson
Apr 30, 2003·Diabetes Care·Richard W GrantJames B Meigs
Jul 10, 2003·JAMA : the Journal of the American Medical Association·Ihab Hajjar, Theodore A Kotchen
Dec 12, 2003·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Sabina De Geest, Eduardo Sabaté
Mar 19, 2004·Journal of Human Hypertension·S RossM J MacLeod
Jun 2, 2006·The New England Journal of Medicine·Thomas G PickeringDonald Haas
Nov 26, 2008·Archives of Internal Medicine·Gil F SallesElizabeth S Muxfeldt
Dec 3, 2010·Journal of Human Hypertension·J BunkerP S Sever
Apr 6, 2011·Circulation·Ian M KronishDevin M Mann
Sep 22, 2011·ClinicoEconomics and Outcomes Research : CEOR·Luca Degli EspostiEzio Degli Esposti
Mar 2, 2012·Circulation·Stacie L DaughertyP Michael Ho
Mar 24, 2012·American Journal of Hypertension·Larissa GrigoryanDavid J Hyman
Apr 17, 2012·Clinics in Geriatric Medicine·Zachary A Marcum, Walid F Gellad
Jul 4, 2012·The American Journal of Medicine·Sayed H NaderiDavid S Wald
Jan 23, 2013·Journal of Hypertension·Oliver JungStefan W Toennes
Apr 13, 2013·Clinical Medicine & Research·Sharon J RolnickRichard J Bruzek
Nov 12, 2013·Journal of Women's Health·Marie ManteuffelAmy Steinkellner
Nov 19, 2013·International Journal of Clinical Pharmacy·Emily Reeve, Michael D Wiese
Dec 10, 2013·Journal of the American College of Cardiology·Stephanie BrinkerWanpen Vongpatanasin
Feb 11, 2014·Journal of Advanced Nursing·Shiah-Lian ChenI-Chen Liao
Mar 17, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Valerie L MorrisonDyfrig A Hughes
Apr 29, 2015·The Journal of Clinical Hypertension·Alejandro VelascoWanpen Vongpatanasin
Aug 22, 2015·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Kathleene WooldridgeSunil Kripalani
Jul 23, 2016·BMJ : British Medical Journal·Mohammed Awais HameedParamjit Gill
May 4, 2017·Hypertension·Pankaj GuptaMaciej Tomaszewski
Jan 24, 2018·BMJ Open·Rachelle Louise CutlerVictoria Garcia-Cardenas

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