Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist

Proceedings of the National Academy of Sciences of the United States of America
Kouji KobiyamaKen J Ishii

Abstract

CpG DNA, a ligand for Toll-like receptor 9 (TLR9), has been one of the most promising immunotherapeutic agents. Although there are several types of potent humanized CpG oligodeoxynucleotide (ODN), developing "all-in-one" CpG ODNs activating both B cells and plasmacytoid dendritic cells forming a stable nanoparticle without aggregation has not been successful. In this study, we generated a novel nanoparticulate K CpG ODN (K3) wrapped by the nonagonistic Dectin-1 ligand schizophyllan (SPG), K3-SPG. In sharp contrast to K3 alone, K3-SPG stimulates human peripheral blood mononuclear cells to produce a large amount of both type I and type II IFN, targeting the same endosome where IFN-inducing D CpG ODN resides without losing its K-type activity. K3-SPG thus became a potent adjuvant for induction of both humoral and cellular immune responses, particularly CTL induction, to coadministered protein antigens without conjugation. Such potent adjuvant activity of K3-SPG is attributed to its nature of being a nanoparticle rather than targeting Dectin-1 by SPG, accumulating and activating antigen-bearing macrophages and dendritic cells in the draining lymph node. K3-SPG acting as an influenza vaccine adjuvant was demonstrated in vivo in both...Continue Reading

References

Dec 31, 1997·The Journal of Experimental Medicine·R S ChuC V Harding
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·C L Brazolot MillanH L Davis
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G Hartmann, A M Krieg
Dec 29, 2000·Nature·H HemmiS Akira
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D VerthelyiD M Klinman
Jan 7, 2004·Biochemical and Biophysical Research Communications·L T CostaS Thalhammer
Apr 2, 2004·Nature Reviews. Immunology·Dennis M Klinman
Aug 12, 2004·Blood·Jurgen HerreGordon D Brown
Jun 10, 2006·Nature Reviews. Drug Discovery·Arthur M Krieg
Jul 26, 2006·The Journal of Experimental Medicine·Cristiana GuiducciFranck J Barrat
Oct 12, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John G McHutchisonHeather L Davis
Jan 9, 2009·European Journal of Immunology·Taiki AoshiMark J Miller
Feb 13, 2009·Advanced Drug Delivery Reviews·Jörg Vollmer, Arthur M Krieg
Jun 10, 2009·The Journal of Experimental Medicine·Kazuhiro SuzukiJason G Cyster
Apr 29, 2010·Science Translational Medicine·Shohei KoyamaKen J Ishii
Apr 22, 2011·Expert Review of Vaccines·Christian BodeDennis M Klinman
Dec 24, 2011·Trends in Immunology·Luisa Martinez-Pomares, Siamon Gordon
Apr 11, 2012·Journal of Innate Immunity·Elizabeth E Gray, Jason G Cyster
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariel E Eberle, Alexander H Dalpke

❮ Previous
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Citations

Nov 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shinichi MochizukiKazuo Sakurai
Oct 21, 2015·Advanced Drug Delivery Reviews·Yoshiro Tahara, Kazunari Akiyoshi
Mar 24, 2016·International Immunology·Burcu TemizozKen J Ishii
Dec 23, 2014·European Journal of Immunology·Burcu TemizozKen J Ishii
Apr 22, 2015·Biomaterials·Sabine SellnerMarkus Rehberg
Sep 23, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jing OuZezhang Tao
Jun 29, 2016·Archives of Pharmacal Research·Sara SalatinMitra Jelvehgari
Nov 20, 2015·Journal of Immunology Research·Cleo Goyvaerts, Karine Breckpot
Mar 1, 2017·Journal of Cellular and Molecular Medicine·Sara Salatin, Ahmad Yari Khosroushahi
Jul 5, 2016·Scientific Reports·Masayuki HayashiKen J Ishii
Mar 10, 2017·Trends in Biotechnology·Timo Johannssen, Bernd Lepenies
Oct 25, 2017·Therapeutic Delivery·Takashi Nakamura, Hideyoshi Harashima
May 17, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohiro KanumaKen J Ishii
Jan 3, 2019·Journal of Drug Targeting·Ana Sara CordeiroMaría José Alonso
Apr 4, 2017·Microbiology and Immunology·Saeko HamaokaTeiji Sawa
Nov 27, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa A KachuraJohn D Campbell
May 1, 2020·Frontiers in Chemistry·Shuyao Lang, Xuefei Huang
Aug 2, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Satoshi Obika, Yuuya Kasahara
Feb 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Motoyasu OnishiKen J Ishii
Mar 28, 2020·Drug Development Research·Rohit Kumar TiwariPreeti Bajpai
Nov 30, 2020·International Immunopharmacology·Rohit Kumar TiwariPreeti Bajpai
Sep 25, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Banu Bayyurt KocabasIhsan Gursel
Mar 27, 2021·Cellular & Molecular Immunology·Rui ZhangZhengfan Jiang

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