Nonalbumin proteinuria predominates in biopsy-proven tenofovir nephrotoxicity

AIDS
Meghan E SiseSumit Mohan

Abstract

Tenofovir disoproxil fumarate (TDF) nephrotoxicity is characterized by proximal renal tubular injury and dysmorphic mitochondria resulting in proteinuria, orthoglycemic glycosuria, and other markers of proximal tubular dysfunction. The objective of this study was to determine the pattern of proteinuria in patients with biopsy-proven TDF nephrotoxicity. Retrospective chart review. Patients with biopsy-proven TDF nephrotoxicity were identified and their medical charts and biopsy reports were reviewed. Comparison was made with HIV-infected patients not on TDF who underwent kidney biopsy. We identified 43 biopsy-proven cases of TDF nephrotoxicity; mean age 54.7 ± 0.4 years, 53% men, 42% whites. Thirty-seven cases reported proteinuria by dipstick of which only 60% had at least 2+ proteinuria. Twenty-seven patients had urine protein quantified by either 24-h collection or spot urine protein-to-creatinine ratio; median proteinuria was 1742 mg/day [interquartile range (IQR) 1200-2000 mg] and 1667 mg/g creatinine (IQR 851-1967 mg/g), respectively. Ten patients had concurrent urinary albumin measured, with a median 236 mg/g creatinine (IQR 137-343 mg/g). The mean urine albumin-to-urine protein ratio (uAPR) was 0.17 (IQR 0.14-0.19), confi...Continue Reading

References

Apr 13, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hélène PeyrièreDominique Salmon-Céron
Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Carolyn L AbitbolGastón Zilleruelo
Jun 24, 2008·The Journal of Antimicrobial Chemotherapy·Inmaculada Jiménez-NácherVincent Soriano
Jun 24, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Noriko OhisaHiroshi Sato
Jan 6, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rikke Nielsen, Erik Ilsø Christensen
Jan 26, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christina M WyattKathryn Anastos
Dec 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Edward R SmithStephen G Holt
Sep 1, 2012·Journal of the American Society of Nephrology : JASN·Piero RuggenentiUNKNOWN BENEDICT Study Investigators
Oct 2, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Michael G ShlipakChirag R Parikh
Oct 2, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Nelson LeungAngela Dispenzieri

❮ Previous
Next ❯

Citations

May 13, 2015·Nature Reviews. Nephrology·Rebecca Scherzer, Michael G Shlipak
Feb 6, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kerry M SheetsGregory M Lucas
Jul 19, 2017·The Pediatric Infectious Disease Journal·Torsak BunupuradahUNKNOWN HIV-NAT 015 Study Team
Sep 25, 2018·Pharmacoepidemiology and Drug Safety·Kedar JoshiSanjay Pujari
Aug 30, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Simon B AscherMichael G Shlipak
Feb 15, 2018·Medicine·Woo Jin JungBaigal Baymbajav
May 21, 2016·Alimentary Pharmacology & Therapeutics·P LamperticoT Berg
May 1, 2016·Current HIV/AIDS Reports·Amit C AchhraChristina M Wyatt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.