Nonalcoholic Fatty Liver Disease--The Clinician's Perspective

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
Swastik Agrawal, Ajay Duseja

Abstract

Non alcoholic fatty liver (NAFLD) is a common cause of liver disease worldwide with prevalence ranging from 10-30%. It encompasses a spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma (HCC) in some patients. The diagnosis of hepatic steatosis can be made reliably by imaging. Differentiating simple steatosis from NASH usually requires liver biopsy although various non-invasive methods are under evaluation. Similarly, liver biopsy is the gold standard for staging of fibrosis but NAFLD fibrosis score and transient elastography are now validated for non-invasive assessment of fibrosis in patients with NAFLD. Liver biopsy should be reserved for patients at high risk of having NASH or advanced fibrosis, those needing evaluation of competing diagnoses or those enrolled in therapeutic trials. Treatment can be directed against various pathophysiological aspects of NAFLD and includes management of obesity, insulin resistance, hyperlipidemia and oxidative stress, suppression of inflammation and modulation of gut bacteria. Lifestyle modification with diet, exercise and weight loss is the cornerstone of therapy. Pharmacological treatment of NAFLD is sti...Continue Reading

Citations

Aug 3, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Juan LiFeiruo Huang
Nov 9, 2019·International Journal of Molecular Sciences·Maheshkumar KannanAntony Joseph Velanganni Arockiam
Nov 30, 2018·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Mallikarjun SakpalYogesh K Chawla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

World Journal of Gastroenterology : WJG
Katherine J P Schwenger, Johane P Allard
La Presse médicale
Maud Lemoine, Lawrence Serfaty
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Jae Sung Ko
Annals of the New York Academy of Sciences
Howard C Masuoka, Naga Chalasani
© 2021 Meta ULC. All rights reserved