Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?

Canadian Journal of Gastroenterology & Hepatology
Ivana MikolasevicZeljko Krznaric

Abstract

The link between metabolic syndrome (MetS) and sarcopenia has not been extensively studied, but it is evident that they share several common features. Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic inflammation, oxidative stress, and crosstalk between organs by secretion of cytokines (hepatokines, adipokines, and myokines). Currently, published studies confirm the association of sarcopenia with the degree of NAFLD defined by liver histology. However, prospective studies that will give us information regarding the causal effect of NAFLD and sarcopenia are still needed. Furthermore, there is a need for a patient-friendly, noninvasive, low-cost method for detection of loss of skeletal muscle mass, strength, and physical performance in the context of NAFLD. Moreover, potential treatment strategies such as physical exercise and nutritional supplementation, that are usually a part of management of sarcopenia, should also be investigated in NAFLD patients, especially given the fact that for now, we do not have a good treatment option for NAFLD. Therefore, future investigations should combine studies on NAFLD and sarcopenia in terms of phy...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Ana Rita de Oliveira Dos SantosJesselina F Dos Santos Haber
Jun 8, 2021·Canadian Journal of Gastroenterology & Hepatology·Lubomir SkladanyTomas Koller

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