Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review

Journal of the American College of Cardiology
Eric P StahlLaurence S Sperling

Abstract

Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both manifestations of end-organ damage of the metabolic syndrome. Through multiple pathophysiological mechanisms, CVD and NAFLD are associated with each other. Systemic inflammation, endothelial dysfunction, hepatic insulin resistance, oxidative stress, and altered lipid metabolism are some of the mechanisms by which NAFLD increases the risk of CVD. Patients with NAFLD develop increased atherosclerosis, cardiomyopathy, and arrhythmia, which clinically result in cardiovascular morbidity and mortality. Defining the mechanisms linking these 2 diseases offers the opportunity to further develop targeted therapies. The aim of this comprehensive review is to examine the association between CVD and NAFLD and discuss the overlapping management approaches.

Citations

Jul 30, 2019·Expert Review of Gastroenterology & Hepatology·Marco ArreseJuan Pablo Arab
Aug 25, 2019·Nutrients·Marja-Riitta TaskinenJan Borén
Feb 12, 2020·Alimentary Pharmacology & Therapeutics·Jacqueline B HensonKathleen E Corey
Mar 3, 2020·Metabolic Syndrome and Related Disorders·Katharina LechnerRonald M Krauss
Apr 13, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Xiaoyan CaiYuli Huang
Jun 3, 2020·Journal of Clinical Medicine·Takemi AkahaneHitoshi Yoshiji
Dec 5, 2019·European Journal of Preventive Cardiology·Arne JanssenPaul Dendale
Aug 20, 2020·Expert Review of Gastroenterology & Hepatology·Tiziana Fernández-MinconeFrancisco Barrera
Jul 18, 2020·Diabetes/metabolism Research and Reviews·Simona Cernea, Itamar Raz
Dec 20, 2019·European Journal of Preventive Cardiology·Paola Dongiovanni, Massimiliano Ruscica
Jan 14, 2020·European Journal of Preventive Cardiology·Katharina LechnerJonathan A Drezner
Sep 15, 2020·Clinical Liver Disease·Naga Swetha SamjiSanjaya K Satapathy
Jun 20, 2019·Journal of Clinical Medicine·Lucia PacificoClaudio Chiesa
Jul 23, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Philipp KasperHans-Michael Steffen
Jul 3, 2020·SAGE Open Medicine·Giandomenico BisacciaSabina Gallina
Jun 25, 2020·MMW Fortschritte der Medizin·Ewert Schulte-Frohlinde
Dec 6, 2020·Current Opinion in Organ Transplantation·Michael Kriss, Scott W Biggins
Dec 30, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Pai-Feng HsuHsin-Bang Leu
Jan 30, 2021·Deutsche medizinische Wochenschrift·Anja FiggeAli Canbay
Feb 1, 2020·Journal of the American College of Cardiology·Thomas A Zelniker, Eugene Braunwald
Nov 6, 2020·Oxidative Medicine and Cellular Longevity·Andrea GonzalezClaudio Cabello-Verrugio
Jan 29, 2021·Canadian Journal of Gastroenterology & Hepatology·Stefan ChiriacAnca Trifan
Nov 17, 2020·World Journal of Clinical Cases·Ugur Arslan, Mustafa Yenerçağ
Feb 4, 2021·Journal of Clinical Medicine·David NiederseerChristian Datz
Feb 25, 2021·European Journal of Preventive Cardiology·Seng Lim Yeoh, Gerard Thomas Flaherty
Apr 4, 2021·Journal of Clinical Medicine·Raluca Pais, Thomas Maurel
Nov 7, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qingmin ZengJia Li
Apr 8, 2021·Journal of Hypertension·Leonardo A SechiCristiana Catena
Apr 18, 2021·Metabolism: Clinical and Experimental·Emir MuzurovićChristos Mantzoros
May 1, 2021·Journal of Clinical Medicine·Mohammad Said RamadanRosa Zampino
May 8, 2021·The Lancet. Gastroenterology & Hepatology·Giovanni TargherChristopher D Byrne
May 19, 2021·ESC Heart Failure·Ana JorbenadzeStefan D Anker

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