Nonalcoholic fatty liver disease-associated hepatocellular carcinoma in a hepatitis B virus-endemic area

European Journal of Gastroenterology & Hepatology
Chang Hwi YoonJin Woo Lee

Abstract

This study was carried out to evaluate the association between nonalcoholic fatty liver disease (NAFLD) and the development of hepatocellular carcinoma (HCC) between 2005 and 2015 in a hepatitis B virus (HBV)-endemic area. The medical records of 1327 patients initially diagnosed with HCC at our institution between January 2005 and December 2015 were analyzed retrospectively. Patients with other malignancies in addition to HCC were excluded. During the study period, changes in the proportion of NAFLD-associated HCC among all HCCs were assessed longitudinally. In addition, the clinical characteristics of NAFLD-associated HCC were evaluated. Among the 1327 patients, HBV was the most common (65.5%) cause of HCC, and the overall rate of NAFLD-associated HCC was 4.7%. Compared with HBV-associated HCC patients, NAFLD-associated HCC patients were older, had a higher median body mass index, and a larger median tumor size (P<0.05 for all). Liver cirrhosis was less frequent in NAFLD-associated than in HBV-associated HCC patients (P<0.05). The annual proportions of NAFLD-associated HCC patients were 3.4% in 2005, 3.6% in 2006, 3.5% in 2007, 3.2% in 2008, 4.2% in 2009, 4.4% in 2010, 5.6% in 2011, 5.2% in 2012, 5.8% in 2013, 7.0% in 2014, an...Continue Reading

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Citations

Aug 1, 2019·The Korean Journal of Internal Medicine·In Tae SoByoung Kuk Jang
Jan 22, 2019·Clinical and Molecular Hepatology·Jung Hwan Yu, Jin-Woo Lee
Dec 15, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Yoon Bin JungGi Hong Choi

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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