Nonalcoholic fatty liver disease, circulating ketone bodies and all-cause mortality in a general population-based cohort.

European Journal of Clinical Investigation
Adrian PostRobin P F Dullaart

Abstract

Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, paralleling the obesity epidemic. Ketone bodies are produced in the liver, but it is currently uncertain whether circulating ketone bodies are increased in the context of NAFLD. We investigated the association between NAFLD and circulating ketone bodies and determined the extent to which NAFLD and circulating ketone bodies are associated with all-cause mortality. Plasma ketone bodies were measured by nuclear magnetic resonance spectroscopy in participants of the general population-based PREVEND study. A fatty liver index (FLI) ≥60 was regarded as a proxy of NAFLD. Associations of an elevated FLI and ketone bodies with all-cause mortality were investigated using Cox regression analyses. The study included 6,297 participants aged 54 ± 12 years, of whom 1,970 (31%) had elevated FLI. Participants with elevated FLI had higher total ketone bodies (194 [153-259] vs 170 [133-243] µmol/L; P < .001) than participants without elevated FLI. During 7.9 [7.8-8.9] years of follow-up, 387 (6%) participants died. An elevated FLI was independently associated with an increased risk of mortality (HR: 1.34 [1.06-1.70]; P = .02). Higher total ketone bodies were also associated with ...Continue Reading

References

Jan 15, 2000·Diabetes/metabolism Research and Reviews·L Laffel
Sep 27, 2000·Journal of the American Society of Nephrology : JASN·Sara-Joan Pinto-SietsmaPaul E DE Jong
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniDavid W Crabb
Feb 11, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Toshiyuki FukaoGrant A Mitchell
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Kristopher J Preacher, Andrew F Hayes
May 3, 2005·The Journal of Clinical Investigation·Kerry L DonnellyElizabeth J Parks
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
Nov 18, 2006·Clinics in Laboratory Medicine·Elias J JeyarajahJames D Otvos
Oct 11, 2008·Brain Research Reviews·Marwan MaaloufMark P Mattson
Jul 16, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Anna KotronenHannele Yki-Järvinen
Aug 20, 2009·Bioinformatics·YounJeong Choi, Christina Kendziorski
Dec 17, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cecilia SöderbergRolf Hultcrantz
Jan 9, 2010·European Journal of Clinical Investigation·I SimeraD G Altman
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Sep 18, 2013·Nature Reviews. Gastroenterology & Hepatology·Rohit Loomba, Arun J Sanyal
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer
Jan 29, 2016·Circulation·Gregory AubertDaniel P Kelly
Apr 12, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
May 24, 2016·Journal of Hepatology·Giovanni TargherCorrado Barbui
Feb 9, 2017·Cell Metabolism·Patrycja Puchalska, Peter A Crawford
May 24, 2017·Nutrients·Christophe Kosinski, François R Jornayvaz
Oct 4, 2017·Health and Quality of Life Outcomes·Geir Fagerjord LoremNina Emaus
Oct 5, 2017·Journal of the American Heart Association·Masaru ObokataMasahiko Kurabayashi
Mar 3, 2018·F1000Research·Sarah FaasseMiriam Vos
Oct 9, 2018·Alimentary Pharmacology & Therapeutics·Aynur Unalp-Arida, Constance E Ruhl
Jul 7, 2019·The Journal of Physiology·Chansol HurrColin N Young
Jan 1, 2020·IJC Heart & Vasculature·Tetsuro YokokawaYasuchika Takeishi
Feb 2, 2020·Metabolism: Clinical and Experimental·Alessandro MantovaniGiovanni Targher
Mar 25, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Mikiko WatanabeLucio Gnessi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of the Indiana State Medical Association
A W MUSSER
Deutsche medizinische Wochenschrift
K DECKER
Nihon rinsho. Japanese journal of clinical medicine
Y HaranoA Suzuki
Laboratornoe delo
A A Gadzhiev, M S Chulkova
© 2021 Meta ULC. All rights reserved