Abstract
To determine if 3.0-T proton-decoupled phosphorus 31 ((31)P) magnetic resonance (MR) spectroscopy can be used to differentiate between stages of nonalcoholic fatty liver disease (NAFLD) by resolving the components of phosphomonoester (PME) and phosphodiester (PDE) and enabling detection of a greater number of other phosphorus-containing compounds. This study was approved by the ethics committee of Helsinki University Central Hospital, and written informed consent was obtained from all study subjects. A 3.0-T clinical imager was used to obtain proton-decoupled (31)P MR spectra in the liver of control subjects (n = 12), patients with biopsy-proved simple steatosis due to nonalcoholic causes (nonalcoholic fatty liver, n = 13; nonalcoholic steatohepatitis [NASH], n = 9), and patients with cirrhosis (n = 9) to determine PME, phosphoethanolamine (PE), phosphocholine, PDE, glycerophosphocholine (GPC), glycerophosphoryl ethanolamine, uridine diphosphoglucose, nicotinamide adenine dinucleotide phosphate (NADPH), inorganic phosphate, phosphoenolpyruvate, and alpha-, beta- and gamma-nucleotide triphosphate levels. Liver fat was determined with hydrogen 1 MR spectroscopy. Differences between the disease groups were analyzed with one-way an...Continue Reading
References
May 1, 1992·NMR in Biomedicine·I J CoxR C Williamson
Mar 1, 1992·Journal of Hepatology·I J CoxS Gilbey
Apr 1, 1989·NMR in Biomedicine·P R LuytenA Heerschap
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D K MenonM Y Morgan
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H N van Wassenaer-van HallW P Mali
Nov 25, 1993·Biochimica Et Biophysica Acta·J D BellJ Urenjak
Jan 1, 1994·Digestive Diseases and Sciences·Y YamaneS Nagataki
Jun 1, 1996·NMR in Biomedicine·C W LiT R Brown
Jan 4, 1998·Journal of Magnetic Resonance·L Vanhamme Van Huffel S
Apr 18, 1998·Gastroenterology·C P Day, O F James
May 8, 1998·Acta Radiologica·K KiyonoT Sodeyama
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Sep 14, 1999·The American Journal of Gastroenterology·E M BruntB R Bacon
Jun 8, 2001·Magma·A NaressiD Graveron-Demilly
Sep 18, 2001·Gut·K K ChanganiJ D Bell
Oct 5, 2001·Seminars in Liver Disease·R Bataller, D A Brenner
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adrian K P LimSimon D Taylor-Robinson
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri, Stephen H Caldwell
Jul 29, 2003·NMR in Biomedicine·Gavin HamiltonSimon D Taylor-Robinson
Mar 3, 2004·Radiology·Cedric M J de BazelaireDavid C Alsop
Sep 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lidia S SzczepaniakRobert L Dobbins
Sep 8, 2004·European Radiology·Bengt NorénOrjan Smedby
Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eduardo FassioCristina Longo
Apr 14, 2005·Journal of Hepatology·Heinz-Peter Wilhelm SchlemmerHelmut Karl Seitz
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Steven F SolgaAnna Mae Diehl
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kristen L ZakianYuman Fong
Mar 9, 2006·Clinical Medicine : Journal of the Royal College of Physicians of London·Chris P Day
Jul 13, 2006·Gastroenterology·Samuele De MinicisDavid A Brenner
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
Jan 30, 2007·Gastroenterology·Jordi ColmeneroPere Ginès
Jul 25, 2007·European Journal of Radiology·Bengt NorenOrjan Smedby
Oct 3, 2007·NMR in Biomedicine·A I SchmidM Roden
Jan 29, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ancha Baranova, Zobair M Younossi
Jun 6, 2008·Alimentary Pharmacology & Therapeutics·M K OhF Poordad
Jun 21, 2008·World Journal of Gastroenterology : WJG·Sanjeev-R MehtaSimon-D Taylor-Robinson
Citations
Mar 22, 2012·Journal of Gastroenterology and Hepatology·Jeremy F L CobboldSimon D Taylor-Robinson
Jul 24, 2013·Radiology·Diana FeierAhmed Ba-Ssalamah
Jun 23, 2012·Radiology·Rutger W van der MeerAlbert de Roos
Mar 1, 2014·Radiology·Nina BastatiAhmed Ba-Ssalamah
Mar 13, 2014·Placenta·S SohlbergJ Wikström
Dec 6, 2014·Magnetic Resonance Imaging Clinics of North America·Maurice B BizinoHildebrandus J Lamb
Feb 26, 2016·Frontiers in Oncology·Wybe J M van der KempDennis W J Klomp
Nov 26, 2015·Magnetic Resonance Imaging·Jurgen J H RungeJ Stoker
Apr 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Martin Krššák
Jun 27, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alessandra LaufsJong-Hee Hwang
Mar 13, 2014·NMR in Biomedicine·Marek ChmelikWolfgang Bogner
Dec 3, 2013·Journal of Hepatology·Jill M AbrigoWinnie C-W Chu
May 27, 2015·NMR in Biomedicine·Alessandra BierwagenMichael Roden
Jan 13, 2015·European Radiology·Marek ChmelíkMartin Krššák
May 4, 2016·Abdominal Radiology·Yoshiki AsayamaHiroshi Honda
Dec 4, 2015·PloS One·Adil BashirJoseph Ackerman
Mar 1, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lucian A B PurvisChristopher T Rodgers
Apr 6, 2017·European Journal of Gastroenterology & Hepatology·Young Mi HongJun Woo Lee
Apr 19, 2017·Scandinavian Journal of Gastroenterology·Lauri PuustinenPerttu Arkkila
Jan 26, 2017·Analytical Biochemistry·Ladislav ValkovičMartin Krššák
Oct 2, 2014·Acta Radiologica·Min Jeong JeonHyeonjin Kim
Oct 7, 2018·Journal of Magnetic Resonance Imaging : JMRI·Lorenz PflegerMarek Chmelík
Mar 16, 2019·Expert Review of Gastroenterology & Hepatology·Laura DraijerBart Koot
Nov 10, 2017·American Journal of Physiology. Endocrinology and Metabolism·Bram BrouwersPatrick Schrauwen
Feb 7, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patricia M NunesArend Heerschap
Sep 14, 2011·Nature Reviews. Endocrinology·Julia SzendroediMichael Roden
May 26, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Stefan TraussniggMichael Trauner
Jul 8, 2017·Journal of Applied Physiology·Jesper Lundbom
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Elizabeth O DanganaLawrence A Olatunji
Nov 28, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Seo Rin Kim, Lilach O Lerman
Jul 3, 2021·International Journal of Molecular Sciences·Nina Krako JakovljevicNebojsa M Lalic
Jul 27, 2021·Frontiers in Physiology·Zohre MozduriCécile M D Bonnefont