Nonalcoholic fatty liver disease: different classifications concordance and relationship between degrees of morphological features and spectrum of the disease

Analytical Cellular Pathology (Amsterdam)
Juliana Maya MonteiroVera Lucia Pannain

Abstract

The morphological features of nonalcoholic fatty liver disease (NAFLD) range from steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Liver biopsy remains the main tool for NASH diagnosis and many histological systems to diagnose and grade NAFLD were proposed. We evaluated the relationship among NAFLD activity score (NAS), histological diagnoses (non-NASH, possible NASH, and definite NASH), and histological algorithm proposed by Bedossa et al.; additionally the degrees of morphological features were semiquantified and correlated with non-NASH and NASH. Seventy-one liver biopsies were studied. The agreement among the three systems considering NASH and non-NASH was excellent (Κ = 0.96). Among the 22 biopsies with NAS 3-4, 72.7% showed to be NASH according to Bedossa's algorithm. The degree of steatosis, ballooning, lobular inflammation, and fibrosis stage were correlated with NASH (P < 0.001). Fibrosis stage 1 was also found in non-NASH. Over the spectrum of NAFLD, no association was observed between intensity of steatosis and fibrosis grade. The degrees of lobular inflammation showed association with fibrosis stage (P < 0.0001). In conclusion, there is agreement among different NAFLD classifications and NAS > 4 may b...Continue Reading

References

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Citations

Oct 28, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Archana RastogiShiv Sarin
Jul 20, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Athina ChasapiGeorgia Sotiropoulou-Bonikou
Sep 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alma ValorCarolina Guzmán
Dec 1, 2018·Journal of Biomedical Optics·Eduardo J Arista RomeuCarolina Guzmán

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Methods Mentioned

BETA
biopsy
biopsies

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