Nonalcoholic Fatty Liver Disease in Children: Hepatic and Extrahepatic Complications

Pediatric Clinics of North America
Praveen Kumar Conjeevaram SelvakumarNaim Alkhouri

Abstract

Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and has become the most common form of chronic liver disease in children and adolescents. The histologic spectrum of NAFLD is broad ranging, from the relatively benign form of simple steatosis to the aggressive form of nonalcoholic steatohepatitis, eventually leading to fibrosis and cirrhosis. NAFLD has also been recognized as an independent risk factor for extrahepatic complications, such as cardiovascular disease, type 2 diabetes mellitus, sleep disorders, and osteoporosis. In this review, we discuss both the hepatic and extrahepatic complications of NAFLD in children.

Citations

Feb 2, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessandro MantovaniGiovanni Targher
Jul 13, 2019·Diabetes/metabolism Research and Reviews·William Javier Morales CamachoBertha Patricia Calderón
Jun 8, 2018·Medical Sciences : Open Access Journal·Sanjoy RoychowdhuryGail A M Cresci
May 10, 2018·Paediatric Drugs·Praveen Kumar Conjeevaram SelvakumarNaim Alkhouri
Mar 27, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni TargherValerio Nobili
Aug 21, 2019·Frontiers in Endocrinology·Ebe D'AdamoValerio Nobili
Apr 24, 2021·Frontiers in Endocrinology·Serena ScapaticciCosimo Giannini
Aug 24, 2021·Frontiers in Endocrinology·Fangli ZhouXiang Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

World Journal of Gastroenterology : WJG
Hakan Fotbolcu, Elçin Zorlu
Current Opinion in Clinical Nutrition and Metabolic Care
Mariana Machado, Helena Cortez-Pinto
Gastroenterología y hepatología
Marta Cobo MartínJavier Crespo
Revista médica del Instituto Mexicano del Seguro Social
Ricardo Salas-FloresAlonso Echegollen-Guzmán
© 2022 Meta ULC. All rights reserved