Abstract
Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and has become the most common form of chronic liver disease in children and adolescents. The histologic spectrum of NAFLD is broad ranging, from the relatively benign form of simple steatosis to the aggressive form of nonalcoholic steatohepatitis, eventually leading to fibrosis and cirrhosis. NAFLD has also been recognized as an independent risk factor for extrahepatic complications, such as cardiovascular disease, type 2 diabetes mellitus, sleep disorders, and osteoporosis. In this review, we discuss both the hepatic and extrahepatic complications of NAFLD in children.
Citations
Dec 9, 2017·Indian Journal of Pediatrics·Naval K Vikram
Feb 2, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessandro MantovaniGiovanni Targher
Jul 13, 2019·Diabetes/metabolism Research and Reviews·William Javier Morales CamachoBertha Patricia Calderón
Aug 6, 2019·BioMed Research International·Shanshan ZhuTangbin Zou
Jun 3, 2020·PloS One·Salman S AlbakheetMi-Jung Lee
Sep 14, 2019·BMC Pediatrics·Susanne Greber-PlatzerUNKNOWN APV-Study Group
Jun 8, 2018·Medical Sciences : Open Access Journal·Sanjoy RoychowdhuryGail A M Cresci
May 10, 2018·Paediatric Drugs·Praveen Kumar Conjeevaram SelvakumarNaim Alkhouri
Mar 27, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni TargherValerio Nobili
Aug 21, 2019·Frontiers in Endocrinology·Ebe D'AdamoValerio Nobili
Jul 11, 2020·Acta Paediatrica·Corina HartmanEli Zuckerman
Oct 18, 2020·Journal of Endocrinological Investigation·C MeleP Marzullo
Feb 7, 2021·Medicine·Yuli SunJianguang Sun
Feb 19, 2021·Clinical Therapeutics·Anandini SuriAjay Jain
Apr 24, 2021·Frontiers in Endocrinology·Serena ScapaticciCosimo Giannini
Aug 24, 2021·Frontiers in Endocrinology·Fangli ZhouXiang Chen