Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options

Drug Design, Development and Therapy
Sandra MilićLidija Orlic

Abstract

Diet and lifestyle changes have led to worldwide increases in the prevalences of obesity and metabolic syndrome, resulting in substantially greater incidence of nonalcoholic fatty liver disease (NAFLD). NAFLD is considered a hepatic manifestation of metabolic syndrome and is related to diabetes, insulin resistance, central obesity, hyperlipidemia, and hypertension. Nonalcoholic steatohepatitis (NASH) is an entity that describes liver inflammation due to NAFLD. Growing evidence suggests that NAFLD is a multisystem disease with a clinical burden that is not only confined to liver-related morbidity and mortality, but that also affects several extra-hepatic organs and regulatory pathways. Thus, NAFLD is considered an important public health issue, but there is currently no effective therapy for all NAFLD patients in the general population. Studies seeking optimal therapy for NAFLD and NASH have not yet led to development of a universal protocol for treating this growing problem. Several pharmacological agents have been studied in an effort to improve insulin resistance and the proinflammatory mediators that may be responsible for NASH progression. Cardiovascular risk factors are highly prevalent among NASH patients, and the backbon...Continue Reading

Citations

Jun 1, 2017·The Nurse Practitioner·Jessica Wisocky, Sonali Paul
Nov 26, 2016·Archives of Pharmacal Research·Mi-Kyung KimMoon-Ho Son
Apr 11, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Luciana M A BorémSergio H S Santos
Dec 6, 2017·Journal of Biological Engineering·Ogechi OgokeNatesh Parashurama
Feb 22, 2018·Canadian Journal of Gastroenterology & Hepatology·Tamara Milovanovic AlempijevicTomica Milosavljevic
Sep 12, 2017·Canadian Journal of Physiology and Pharmacology·Hayam AteyyaNagla A El-Sherbeeny
Apr 5, 2018·Nutrients·Mahmud MahamidAbdulla Watad
Jan 31, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Tingting ShiJunping Shi
Aug 31, 2019·Medicina·Luka VranićSandra Milić
Jun 22, 2017·Terapevticheskiĭ arkhiv·V A Akhmedov, O V Gaus
Jun 23, 2020·Canadian Journal of Gastroenterology & Hepatology·Blanca Martínez SorianoJosé J García
Dec 16, 2018·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Chongye FangJun Sheng
Aug 31, 2017·Journal of Agricultural and Food Chemistry·Long WangFeijun Luo

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
gastric bypass
biopsy

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

Minerva gastroenterologica e dietologica
A SourianarayananeJ P Kirwan
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Sumio WatanabeTooru Shimosegawa
European Journal of Gastroenterology & Hepatology
Giovanni TarantinoRaffaela Vecchione
© 2021 Meta ULC. All rights reserved