PMID: 6966289Jun 1, 1980Paper

Nonantibiotic effects of macrolide antibiotics of the oleandomycin-erythromycin group with special reference to their "steroid-sparing" effects

The Journal of Allergy and Clinical Immunology
W M SelenkeR G Townley

Abstract

Certain macrolide antibiotics, such as troleandomycin (TAO), oleandomycin, and erythromycin estolate (Ilosone), can lower the maintenance dose of glucocorticoids required by severely asthmatic patients. These effects were postulated to be caused by an as yet undefined steroid-sparing effect. In this study, TAO in combination with methylprednisolone, when compared with methylprednisolone alone, was demonstrated to significantly increase liver glycogen deposition in adrenalectomized mice, intact mice, and adrenalectomized rats; protect histamine-sensitized mice following beta adrenergic blockade or adrenalectomy; further decrease the steroid-lowered glucose tolerance of mice and significantly increase the plasma corticosteroid levels in rats. TAO alone did not have these effects. TAO plus betamethasone, and erythromycin estolate plus methylprednisolone also increased liver glycogen deposition. However, TAO did not appear to potentiate the effects of hydrocortisone. Erythromycin stearate and to a lesser degree erythromycin ethylsuccinate when combined with methylprednisolone also decreased histamine lethality in mice. Leucomycin and tetracycline did not enhance the effects of methylprednisolone. TAO, alone or with methylprednisolo...Continue Reading

References

Mar 1, 1977·The Journal of Allergy and Clinical Immunology·M WeinbergerC Chidsey
Aug 24, 1972·The New England Journal of Medicine·H N Claman
Mar 1, 1970·The Journal of Allergy·I H Itkin, M L Menzel
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Feb 1, 1964·The Journal of Pharmacy and Pharmacology·P GOADBY, W G SMITH
Dec 1, 1948·Proceedings of the Society for Experimental Biology and Medicine·J LEGERB ROSE

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Citations

Jan 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·W F EblingW J Jusko
Nov 13, 2010·Inflammopharmacology·Michael W Whitehouse
Oct 1, 1982·Journal of the American Academy of Dermatology·B J FoxR F Findlay
Feb 15, 2001·Clinics in Dermatology·G L Capella, A F Finzi
Oct 1, 1992·Journal of Clinical Pharmacy and Therapeutics·H W Kelly
Feb 12, 2002·Pharmacotherapy·Allyson S Gaylor, Joan C Reilly
Nov 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L K Pershing, M R Franklin
Mar 21, 2006·Journal of the American Academy of Dermatology·Abdulmajeed AlajlanIssam R Hamadah
Apr 12, 2001·The British Journal of Dermatology·J PowellF Wojnarowska

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