Noncholesterol sterols in bile and stones of patients with cholesterol and pigment stones

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
T A MiettinenTatu A Miettinen

Abstract

Human bile and cholesterol gallstones contain sterols including methylated (lanosterol and other dimethyl and monomethyl sterols), and demethylated cholesterol precursor sterols (delta 8-lathosterol, lathosterol, and desmosterol), plant sterols (campesterol and sitosterol), and cholestanol. The aim of the study was to analyze the noncholesterol sterols in gallbladder bile and stones from female and male patients with cholesterol stones (CS) and pigment stones (PS) to ascertain whether any sterol fraction contributes to the gallstone formation. Classification of gallstones to CS and PS was performed on the basis of the stone cholesterol content. The study group consisted of 165 consecutive cholecystectomized patients, 150 with CS and 15 with PS. Bile acids and sterols were quantitated using gas-liquid chromatography (GLC). The biliary lipid and noncholesterol sterol/cholesterol proportions were similar in the CS and PS patients. The proportions of methylated and plant sterols were significantly lower in the CS than in bile, whereas those of delta 8-lathosterol, lathosterol, and cholestanol were significantly higher. The PS, in contrast to the CS, were neither sex nor weight related. The bile acid and phospholipid concentrations ...Continue Reading

Citations

Aug 22, 2006·Expert Review of Cardiovascular Therapy·Jennifer G Robinson, Michael H Davidson
Jun 1, 1997·Annals of Medicine·D Lütjohann, K von Bergmann
Jul 28, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A I KoivusaloM J Nissinen
Jan 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marcin KrawczykJuan Francisco Miquel
Jul 1, 2015·BMC Gastroenterology·Antti KoivusaloMarkku J Nissinen
Feb 4, 1999·Scandinavian Journal of Gastroenterology·T E Miettinen, M Vuoristo
Sep 8, 2016·Journal of Pediatric Gastroenterology and Nutrition·Markku J NissinenMikko P Pakarinen

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