Noncirrhotic portal hypertension

Journal of Clinical and Experimental Hepatology
Harshal RajekarRadha K Dhiman

Abstract

Portal hypertension is characterized by an increase in portal pressure (> 10 mmHg) and could be a result of cirrhosis of the liver or of noncirrhotic diseases. When portal hypertension occurs in the absence of liver cirrhosis, noncirrhotic portal hypertension (NCPH) must be considered. The prognosis of this disease is much better than that of cirrhosis. Noncirrhotic diseases are the common cause of portal hypertension in developing countries, especially in Asia. NCPH is a heterogeneous group of diseases that is due to intrahepatic or extrahepatic etiologies. In general, the lesions in NCPH are vascular in nature and can be classified based on the site of resistance to blood flow. In most cases, these disorders can be explained by endothelial cell lesions, intimal thickening, thrombotic obliterations, or scarring of the intrahepatic portal or hepatic venous circulation. Many different conditions can determine NCPH through the association of these various lesions in various degrees. Many clinical manifestations of NCPH result from the secondary effects of portal hypertension. Patients with NCPH present with upper gastrointestinal bleeding, splenomegaly, ascites after gastrointestinal bleeding, features of hypersplenism, growth re...Continue Reading

Citations

Sep 14, 2018·World Journal of Nephrology·Prani PakaPrakash Narayan
Nov 15, 2016·Abdominal Radiology·Lauren N Moomjian, Sarah G Winks
Feb 24, 2016·Journal of Investigative Medicine High Impact Case Reports·Saman RatnayakeGreti Petersen
Feb 21, 2019·Arquivos De Gastroenterologia·Juliana Arrais GuerraCláudia Alexandra Pontes Ivantes
May 27, 2015·Clinical Liver Disease·Josep MartiMyron Schwartz
Jan 30, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Abdulrhman S ElnaggarJean C Emond
Sep 29, 2015·Clinical Liver Disease·Ohad EtzionTheo Heller
Jun 18, 2021·Indian Journal of Pathology & Microbiology·Archana George VallonthaielPrasenjit Das

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