Noncirrhotic portal hypertension

Current Opinion in Gastroenterology
Ben L DaTheo Heller

Abstract

Noncirrhotic portal hypertension represents a heterogeneous group of liver disorders that is characterized by portal hypertension in the absence of cirrhosis. The purpose of this review is to serve as a guide on how to approach a patient with noncirrhotic portal hypertension with a focus on recent developments. Recent studies pertaining to noncirrhotic portal hypertension have investigated aetiological causes, mechanisms of disease, noninvasive diagnostic modalities, clinical characteristics in the paediatric population and novel treatment targets. Noncirrhotic portal hypertension is an underappreciated clinical entity that can be difficult to diagnosis without a healthy suspicion. Diagnosis then relies on a comprehensive understanding of the causes and clinical manifestations of this disease, as well as a careful interpretation of the liver biopsy. Noninvasive approaches to diagnosis may play a significant role moving forward in this disease. Treatment in NCPH remains largely targeted at the individual sequalae of portal hypertension.

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Aug 2, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Virginia Hernández-GeaJuan Carlos Garcia-Pagán
Jul 25, 2019·Annals of Vascular Surgery·Luca RoncatiGraziana Gallo

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