Noncoding microRNAs: small RNAs play a big role in regulation of ADME?

Acta Pharmaceutica Sinica. B
Ai-Ming Yu, Yu-Zhuo Pan

Abstract

There are considerable interindividual variations in drug absorption, distribution, metabolism and excretion (ADME) in humans, which may lead to undesired drug effects in pharmacotherapy. Some of the mechanistic causes are known, e.g., genetic polymorphism, inhibition and induction of ADME enzymes and transporters, while others such as posttranscriptional regulation of ADME genes are under active study. MicroRNAs (miRNAs) are a large group of small, noncoding RNAs that control posttranscriptional expression of target genes. More than 1000 miRNAs have been identified in the human genome, which may regulate thousands of protein-coding genes. Some miRNAs directly or indirectly control the expression of xenobiotic-metabolizing cytochrome P450 enzymes, ATP-binding cassette or solute carrier transporters and/or nuclear receptors. Consequently, intervention of miRNA epigenetic signaling may alter ADME gene expression, change the capacity of drug metabolism and transport, and influence the sensitivity of cells to xenobiotics. In addition, the expression of some ADME regulatory miRNAs is significantly changed in cells following the exposure to a given drug, and the consequent changes in ADME gene expression might result in distinct ADME...Continue Reading

Citations

Aug 7, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Magnus Ingelman-SundbergYoichi Osawa
Aug 28, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mei-Mei LiAi-Ming Yu
Aug 2, 2018·Anais Da Academia Brasileira De Ciências·Ricardo I CastroLuis Guzmán
May 21, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yu-Zhuo PanAi-Ming Yu
Nov 15, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ai-Ming YuJoseph L Jilek
Mar 25, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jessica K RiegerUlrich M Zanger
Apr 9, 2016·Stem Cells Translational Medicine·Dagmara SzkolnickaDavid C Hay
Jan 1, 2015·Nuclear Receptor Research·Chandra PrakashBandana Chatterjee
Oct 12, 2018·Molecular and Cellular Biochemistry·Finosh G ThankamDevendra K Agrawal
Nov 2, 2020·Thérapie·Anaëlle ChavantFrançoise Stanke-Labesque
Aug 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Faye ChleilatRaylene A Reimer
Aug 13, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Shujing RenBaojian Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.