Noncoding RNA control of cellular senescence

Wiley Interdisciplinary Reviews. RNA
Kotb Abdelmohsen, Myriam Gorospe

Abstract

Senescent cells accumulate in normal tissues with advancing age and arise by long-term culture of primary cells. Senescence develops following exposure to a range of stress-causing agents and broadly influences the physiology and pathology of tissues, organs, and systems in the body. While many proteins are known to control senescence, numerous noncoding (nc)RNAs are also found to promote or repress the senescent phenotype. Here, we review the regulatory ncRNAs (primarily microRNAs and lncRNAs) identified to-date as key modulators of senescence. We highlight the major senescent pathways (p53/p21 and pRB/p16), as well as the senescence-associated secretory phenotype (SASP) and other senescence-associated events governed by ncRNAs, and discuss the importance of understanding comprehensively the ncRNAs implicated in cell senescence.

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Jan 10, 1998·The Journal of Pathology·W ChenH Tiedge
Jul 23, 1998·Critical Reviews in Eukaryotic Gene Expression·V J CristofaloM Tresini
Oct 6, 1999·Current Biology : CB·D N SheltonW D Funk
Jan 9, 2001·Frontiers in Bioscience : a Journal and Virtual Library·A NavarroM J Sánchez del Pino
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KrtolicaJ Campisi
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hong ZhangStanley N Cohen
Jun 25, 2003·Molecular Cell·Cary K LaiKathleen Collins
Mar 1, 1965·Experimental Cell Research·L HAYFLICK
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Xun ZhangAnne Klibanski
Jul 23, 2004·Current Biology : CB·Arthur J Lustig
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Nov 16, 2004·Mechanisms of Ageing and Development·Vincent J CristofaloMaria Tresini
Dec 3, 2004·Molecular Biology of the Cell·K HardyP S Jat
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Ittai Ben-Porath, Robert A Weinberg
Aug 5, 2005·Nature·Manuel ColladoManuel Serrano
Aug 5, 2005·Nature·Chrysiis MichaloglouDaniel S Peeper
Dec 13, 2005·The Journal of Biological Chemistry·Arturo RossoMaria Felice Brizzi
Apr 18, 2006·Biochemical and Biophysical Research Communications·Chang-Su Lim
Aug 2, 2006·The Journal of Biological Chemistry·Jean-Philippe CoppéChristian M Beauséjour
Sep 8, 2006·Nature·Janakiraman KrishnamurthyNorman E Sharpless
Nov 14, 2006·Nature Structural & Molecular Biology·Glen M BorchertBeverly L Davidson
Apr 11, 2007·Molecular and Cellular Biology·Margarida RuasGordon Peters
Sep 6, 2007·PloS One·Imad J MatoukEithan Galun
Sep 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi TazawaHitoshi Nakagama
Dec 7, 2007·Mechanisms of Ageing and Development·Kathleen Collins
Dec 25, 2007·Nature Cell Biology·Stefan Schoeftner, Maria A Blasco
Feb 26, 2008·Nature Cell Biology·Arthur P YoungWilliam G Kaelin
Mar 28, 2008·PloS One·Ashish LalMyriam Gorospe

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Citations

Dec 15, 2015·Ageing Research Reviews·Sukhleen Kour, Pramod C Rath
Dec 24, 2015·Frontiers in Medicine·Cristina Sorina CătanăIoana Berindan-Neagoe
May 18, 2016·Experimental and Molecular Pathology·Jingying HouTong Wang
Aug 18, 2016·Wiley Interdisciplinary Reviews. RNA·Douglas F DluzenMichele K Evans
Feb 2, 2017·The Journal of Clinical Investigation·Ana L MoraMauricio Rojas
Jul 14, 2017·Aging Cell·Mathieu Deschênes, Benoit Chabot
Aug 2, 2017·Antioxidants & Redox Signaling·Rosa VonoPaolo Madeddu
Dec 5, 2017·BMC Pulmonary Medicine·Yulin GaoXiaodong Song
Dec 1, 2018·RNA Biology·Anna RothSven Diederichs
Jul 9, 2016·The European Respiratory Journal·Moisés SelmanAnnie Pardo
May 31, 2019·International Journal of Molecular Sciences·Pavan Kumar Puvvula
Feb 20, 2019·Aging·Nicole Noren Hooten, Michele K Evans
Nov 20, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joseph L Dempsey, Julia Yue Cui
Jul 30, 2018·Aging Medicine·Jieyu HeYoushuo Liu
May 31, 2019·Wiley Interdisciplinary Reviews. RNA·Gabriel CasellaMyriam Gorospe
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Xueke ZhouXin Li
Jul 5, 2019·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Samuel HamiltonMichel Bernier

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