Noncoding RNA for personalized prostate cancer treatment: utilizing the 'dark matters' of the genome

Personalized Medicine
Junjie HuaHousheng Hansen He

Abstract

Prostate cancer is the most commonly diagnosed cancer in men in western countries, with significant health impact. Clinically, it is complicated with the lack of biomarkers and effective treatments for aggressive disease, particularly castration-resistant prostate cancer. Although we have gained much insight into the biology of prostate cancer through studying protein-coding genes, they represent only a small fraction of our genome. Therefore, it is essential for us to investigate noncoding RNAs, which comprise the majority of our transcriptome, in order to achieve a better understanding of prostate cancer and move toward personalized medicine. In this article, we will address recent advancements in our knowledge of noncoding RNAs, and discuss the clinical potentials and challenges of different types of noncoding RNAs in prostate cancer.

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Methods Mentioned

BETA
Antisense oligonucleotide
biopsy
surgical resection
antisense oligonucleotides
PCR

Clinical Trials Mentioned

NCT02366494
NCT02471469
NCT00466583
NCT00120288
NCT00159028

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