Noncoding RNAs in acute kidney injury

Journal of Cellular Physiology
Gui-Ling RenXiao-Ming Meng

Abstract

Acute kidney injury (AKI), caused by various stimuli including ischemia reperfusion, nephrotoxic insult, and sepsis, is characterized by abrupt decline of kidney function. Till now, the molecular mechanisms for AKI have not been fully explored and the effective therapies are still lacking. Noncoding RNAs (ncRNAs), a group of biomolecules function at RNA level, are involved in a wide range of physiopathological processes including AKI. MicroRNAs (miRNAs) are the most extensively studied ncRNAs in AKI. Evidence indicated that miRNAs are altered significantly in various types of AKI. Gain-and-loss-of-function studies demonstrated that miRNAs, such as miR-24, miR-126, miR-494, and miR-687, may bind to the 3'-untranslated region of their target genes to regulate inflammation, programmed cell death, and cell cycle in the injury and repair stages of AKI, indicating their therapeutic potential in AKI. In contrast, functions of long noncoding RNAs and circular RNAs in AKI are hot topics but still largely unknown. Additionally, ncRNAs packaged in exosome can be detected in circulation and urine, they may serve as specific biomarkers for AKI. This review summarized the alteration and functional role of ncRNAs and their therapeutic potenti...Continue Reading

References

Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·N StavropoulosJ T Lee
Dec 21, 2002·Trends in Genetics : TIG·Katharine L Arney
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
Mar 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sushrut S WaikarGlenn M Chertow
Mar 29, 2008·Cell Stem Cell·Benjamin D HumphreysJoseph V Bonventre
Apr 15, 2008·FEBS Letters·Fang SunXiaofei Zheng
May 28, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·David Sáenz-MoralesMaría Laura García-Bermejo
Feb 11, 2010·Cancer Research·Lorenzo GalluzziGuido Kroemer
Apr 3, 2010·Journal of the American Society of Nephrology : JASN·Qingqing WeiZheng Dong
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Jul 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jonathan G GodwinJohn Iacomini
Aug 27, 2010·Cold Spring Harbor Perspectives in Biology·Jeannie T Lee
Oct 12, 2010·RNA Biology·Tiffany Hung, Howard Y Chang
Mar 23, 2011·Nature Reviews. Nephrology·Johan M LorenzenThomas Thum
Jun 28, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Johan M LorenzenThomas Thum
Jul 8, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Jason K Molitoris, Bruce A Molitoris
Dec 14, 2011·Kidney International·Ion D BucaloiuRobert M Perkins
Apr 12, 2012·Nucleic Acids Research·Victoria A MoranAhmad M Khalil
Jun 19, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Janani SaikumarVishal S Vaidya
Oct 30, 2012·The EMBO Journal·Xuefeng LiuQimin Zhan
Nov 20, 2012·Journal of the American Society of Nephrology : JASN·Yi-Fan LanHeng Lin
Mar 7, 2013·Nature Structural & Molecular Biology·Tim R Mercer, John S Mattick
Apr 6, 2013·Nucleic Acids Research·Qian LiuYin-Yuan Mo
Jul 10, 2013·Current Drug Targets·Hugo SecaM Helena Vasconcelos
Jul 25, 2013·Cellular and Molecular Life Sciences : CMLS·Masatoshi KitagawaTatsuya Ohhata
Aug 31, 2013·Nucleic Acid Therapeutics·Tamás KaucsárPéter Hamar

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Citations

Apr 11, 2019·American Journal of Physiology. Cell Physiology·Zhiwen LiuZheng Dong
Oct 27, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ling JiangXiao-Ming Meng
Apr 26, 2020·Journal of Cellular and Molecular Medicine·Juan JinXiao-Ming Meng
Jul 7, 2019·Molecular Cancer·Yangxia WangLiang Ming
Apr 29, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Shijun LuChao Ning
Nov 18, 2020·Drug and Chemical Toxicology·Xiaoqin LiuChunyang Jiang
Mar 19, 2021·DNA and Cell Biology·Huiwen Ren, Qiuyue Wang
May 13, 2021·Cancer Cell International·Yihan Fu, Hong Sun
Jul 10, 2021·Journal of Clinical Laboratory Analysis·Hai-Yuan LuHai-Tao Jiang
Jul 27, 2021·Frontiers in Medicine·Elena Cantero-NavarroMarta Ruiz-Ortega

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