Noncoding RNAs in cardiovascular diseases

Current Opinion in Cardiology
Priyatansh Gurha

Abstract

Human genome is pervasively transcribed, producing coding and noncoding RNAs. Recent studies have revealed the roles of a class of noncoding RNAs, the long noncoding RNAs (lncRNAs), in heart failure and other cardiovascular diseases. This review provides a brief summary of recent findings on lncRNA function. Recent studies have documented the roles of lncRNAs in cardiac regeneration, conduction, hypertrophy/dysfunction, and endothelial function. LncRNAs perform these functions through acting as competing RNA (by binding and sequestering MicroRNAs) or acting as guides to protein targeting. A few lncRNAs also encode small peptides (e.g., Dwarf Open Reading Frame RNA) and in the context of heart regulate cardiac calcium homeostasis. Noncoding RNA provides a versatile mechanism of gene regulation and thereby present as novel targets for intervention in various cardiovascular disease. Future studies aimed at defining the context-dependent lncRNA mechanisms will be required to advance our understanding and relish the goal of RNA therapeutics.

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Citations

Jul 25, 2019·Cardiovascular Drugs and Therapy·Vince SiebertYochai Birnbaum
Aug 6, 2019·Frontiers in Cardiovascular Medicine·Paras Kumar Mishra, Georges Nemer
Jul 16, 2020·Non-coding RNA·Marcin WysoczynskiShizuka Uchida
Oct 30, 2020·Frontiers in Physiology·Julia Mester-TonczarMariann Gyöngyösi
Nov 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaomin YangYong Wang
Jan 23, 2021·Diagnostics·Nurruzanna IsmailSiti Aishah Sulaiman
Jun 21, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
May 25, 2021·Frontiers in Cardiovascular Medicine·Dandan SongJunnan Wang

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