PMID: 6167557Mar 1, 1981Paper

Noncodominant expression of target antigens recognized by human cytotoxic T lymphocytes

Human Immunology
D J Schendel, R Wank

Abstract

Human CTL that recognized MHC-controlled determinants distinct from HLA-A. B, C, and D/DR antigens were tested in a family with nine siblings. Segregation analysis of positive CML reactions showed strong lysis of target cells of three HLA-identical siblings, inheriting the b and c MHC haplotypes (blc), but not of the parents or siblings inheriting only one of these haplotypes. Some cytotoxicity was seen against parental target cells, although it seemed to be qualitatively distinct from that directed against the b/c targets. Studies using the competitive inhibition technique showed that cells inheriting only the b or c haplotypes were not effective in decreasing the specific cytotoxicity. Furthermore, simultaneous inclusion of inhibitor cells of both the b and c haplotypes did not hinder the specific cytotoxicity. Induction of CTL recognizing this new determinant did not occur when either antigens of the b or c haplotypes were used as MLC stimulating cells, or when antigens of both haplotypes were presented simultaneously, but on separate stimulating cells, in a three-cell MLC. These results suggest that the target determinant recognized by these unusual CTL is complex; it may be formed through interactions of two surface molecu...Continue Reading

References

Oct 21, 1976·The New England Journal of Medicine·F H Bach, J J van Rood
Jan 1, 1976·Transplantation Reviews·V P EijsvoogelW P Zeijlemaker
Oct 7, 1976·The New England Journal of Medicine·F H Bach, J J van Rood
Oct 14, 1976·The New England Journal of Medicine·F H Bach, J J Rood
Apr 7, 1977·Nature·E GoulmyJ J van Rood

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