Noncompaction in Duchenne muscular dystrophy: frustrated attempt to create a compensatory left ventricle?

Cardiology
Josef FinstererHans Feichtinger

Abstract

The histological workup of the myocardium of a patient with Duchenne muscular dystrophy and left ventricular hypertrabeculation/noncompaction (LVHT) revealed an extremely thin left ventricular wall and a noncompacted layer double in size compared to the compacted layer. Within the compacted layer islets of fibrous tissue predominated, surrounded by areas of myxoid appearance hardly producing collagen, and occasionally normal or dystrophic cardiomyocytes. The noncompacted layer consisted largely of intact cardiomyocytes rarely intermingled with collagen-producing, fibrous tissue. This variant appearance of the compacted and noncompacted layer was found in all areas of noncompaction. These histopathological findings suggest that LVHT represents a compensatory attempt to overcome the failing compacted but dystrophic myocardium.

References

Jan 9, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Claudia Stöllberger, Josef Finsterer
Jul 6, 2005·Zeitschrift für Kardiologie·T SüselbeckT Papavassiliu

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Citations

Nov 2, 2006·Cardiology·Josef FinstererHans Feichtinger
Aug 7, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher J StatileKan N Hor
Dec 26, 2006·Expert Review of Cardiovascular Therapy·DeWayne TownsendJoseph Metzger
Apr 4, 2009·International Journal of Cardiology·Josef FinstererElisabeth Bonner
Feb 17, 2007·International Journal of Cardiology·Josef FinstererHans Feichtinger
Sep 18, 2007·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Josef FinstererHans Feichtinger
Nov 18, 2006·International Journal of Cardiology·Martin HoferJosef Finsterer
Jul 5, 2011·The American Journal of Cardiology·William Clifford RobertsDan Marshall Meyer
Feb 12, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Kyla D HuebnerJudy E Anderson

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