PMID: 3320921Oct 1, 1987Paper

Noncomparative, open label, multicenter trial of cefixime for treatment of bacterial pharyngitis, cystitis and pneumonia in pediatric patients

The Pediatric Infectious Disease Journal
W L RisserD L Simpkins

Abstract

Cefixime, a new third generation oral cephalosporin antibiotic, was evaluated for safety and efficacy in the treatment of 206 children with acute bacterial pharyngitis, cystitis or pneumonia. Each patient had a throat, urine or sputum culture before therapy and was treated with a 10- to 14-day course of cefixime, 8 mg/kg once daily. Bacterial pathogens were isolated in 167 of 206 (81.1%). Streptococcus pyogenes (73.7% of isolates) and Escherichia coli (9.6%) were the most common Gram-positive and Gram-negative organisms, respectively. All patients were evaluable for safety, and 109 (52.9%) with pharyngitis (96) or cystitis (13) were evaluable for efficacy. Clinical failure occurred in 2 of 109 (1.8%) patients, both with pharyngitis; bacteriologic failure occurred in 1 patient with pharyngitis and 1 with cystitis. Five patients with pneumonia caused by possible pathogens also improved while taking cefixime. Drug-related adverse side effects occurred in 50 of 206 patients (24.3%); these were generally mild and led to discontinuing the antibiotic in only 4 patients (1.9%). The most common were diarrhea or loose stools (33 of 206, or 16%). Results of this study suggest that cefixime given once daily to children is safe and effectiv...Continue Reading

Citations

Jul 1, 1995·International Journal of Antimicrobial Agents·J A García-RodríguezJ E García Sánchez
Aug 4, 2010·Analytical Biochemistry·Rajeev JainK Radhapyari
Apr 28, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tawfeeg A NajjarSherif Y Saad
Mar 1, 1993·Pediatric Annals·S S Long
May 2, 2001·Journal of Chemotherapy·V Fanos, L Cataldi
Jan 1, 1990·Infection·H Helwig
May 1, 1990·DICP : the Annals of Pharmacotherapy·N J LeggettM J Rybak
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Mar 1, 1989·Biopharmaceutics & Drug Disposition·R D FaulknerB M Silber
Jan 1, 1990·DICP : the Annals of Pharmacotherapy·G H Smith

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