Noncontrast Breast MRI During Pregnancy Using Diffusion Tensor Imaging: A Feasibility Study
Abstract
Pregnancy-associated breast cancer (PABC) is often a delayed diagnosis and contrast-enhanced MRI is contraindicated because gadolinium agents are known to cross the placenta. To investigate the feasibility and clinical utility of noncontrast breast MRI using diffusion tensor imaging (DTI) in the diagnostic workup of PABC. Prospective. Between November 2016 and January 2018, 25 pregnant participants (median gestational age: 17 weeks) were recruited from eight referral breast-care centers nationwide. Imaging indications included: newly-diagnosed PABC (n = 10, with 11 lesions), palpable mass/mastitis (n = 4), high-risk screening (n = 10), and monitoring neoadjuvant-chemotherapy response (n = 1). 1.5T, T2 -weighted, and DTI sequences, prone position, with a scan duration of ∼12 minutes. DTI parametric maps were generated and analyzed at pixel resolution, with reference to ultrasound (US) and pathology. Two-tailed Student's t-test was applied for evaluating differences between DTI parameters of PABC vs. healthy fibroglandular tissue. Pearson's correlation test was applied to measure the agreements between λ1-based longest tumor diameter, US, and pathology. All scans were technically completed and reached diagnostic quality, except o...Continue Reading
References
Breast imaging of the pregnant and lactating patient: physiologic changes and common benign entities
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