Nonconventional genetic risk factors for cardiovascular disease.

Current Atherosclerosis Reports
Christopher N TymchukHooman Allayee

Abstract

Despite numerous advances made in identifying the genes for rare mendelian forms of cardiovascular disease (CVD), relatively little is known about the common, complex forms at the genetic level. Moreover, most genes that have been associated with CVD, whether they are single gene forms or more common forms of the disease, have primarily been involved in biochemical pathways related to what are considered "conventional" risk factors. However, recent genetic studies have begun to identify genes and pathways associated with CVD that would not be considered to underlie conventional risk factors. In this review, we discuss the evidence for this latter notion based on recent linkage and association studies in humans. As an example, we also illustrate how a combination of mouse and human genetics led to identification of the 5-lipoxygenase pathway for CVD, with potentially important implications for its treatment and diagnosis. We conclude with a discussion of the prospects for identifying CVD genes in the future and for potentially developing more effective therapeutic strategies.

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Citations

Feb 5, 2011·Human Genetics·Jaana HartialaHooman Allayee
Sep 1, 2009·Human Molecular Genetics·Susanna VikmanHooman Allayee
Sep 25, 2009·Journal of Nutrigenetics and Nutrigenomics·Hooman AllayeeHoward N Hodis
Mar 2, 2012·The American Journal of Clinical Nutrition·Jaana HartialaHooman Allayee
Oct 10, 2008·The American Journal of Clinical Nutrition·Hooman AllayeeHannia Campos

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