Noncoordinate regulation of epithelial Na channel and Na pump subunit mRNAs in kidney and colon by aldosterone

The American Journal of Physiology
B EscoubetN Farman

Abstract

Distal colon and renal cortical collecting ducts are major effectors of aldosterone-dependent Na homeostasis. Na is absorbed by entry through an apical amiloride-sensitive Na channel and extruded by Na-K-ATPase at the basolateral membrane. Using a ribonuclease protection assay, we studied, in vivo, aldosterone regulation of alpha-, beta-, gamma-subunits of the rat epithelial Na channel (rENaC) and alpha 1- and beta 1-subunits of Na-K-ATPase. In the kidney, Na-K-ATPase mRNAs were also assayed over discrete tubular segments by in situ hybridization. In rat colon, all three rENaC mRNAs were decreased by adrenalectomy, with a major effect on beta- and gamma-subunits, and were restored with 7 days, but not 2 days, of aldosterone treatment; in the kidney, however, only alpha-transcripts varied. Na-K-ATPase alpha 1- and beta 1-subunit mRNAs in both organs were not (in the case of the beta 1-subunit) or were mildly (in the case of the alpha 1-subunit) affected after adrenalectomy. Our conclusions are as follows: 1) Transcripts of rENaC and Na-K-ATPase subunits are not coordinately regulated by aldosterone in vivo; i.e., modulation involves mainly the Na channel, not Na-K-ATPase; the effect is not of comparable magnitude on each subunit...Continue Reading

References

Oct 1, 1983·Pflügers Archiv : European journal of physiology·G El Mernissi, A Doucet
May 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H Garty
Jul 1, 1993·The Journal of General Physiology·J PáchaL G Palmer
Jul 1, 1993·The Journal of General Physiology·L G PalmerG Frindt

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Citations

Jan 23, 1999·Current Opinion in Nephrology and Hypertension·N Farman
Jan 12, 2001·Physiological Reviews·S Muto
Mar 16, 2001·American Journal of Physiology. Renal Physiology·J LoffingF Verrey
Jun 28, 2002·Physiological Reviews·Michael A MatthayChristine Clerici
Jun 20, 2002·The Journal of Biological Chemistry·Sheerazed BoulkrounNathalie Courtois-Coutry
Dec 31, 2002·American Journal of Physiology. Renal Physiology·Omar A ItaniChristie P Thomas
Jan 17, 2003·American Journal of Physiology. Cell Physiology·Angelos-Aristeidis Konstas, Christoph Korbmacher
Dec 22, 2004·Pflügers Archiv : European journal of physiology·Olga SoutourinaAlain Doucet
Jun 16, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zhenrong YuBruno Vogt
Oct 21, 2005·American Journal of Physiology. Cell Physiology·Wenzheng ZhangBruce C Kone
Sep 6, 2005·Pflügers Archiv : European journal of physiology·Sheerazed BoulkrounNathalie Courtois-Coutry
Sep 17, 2005·Glycobiology·Maurice BicharaNicolette Farman
Mar 3, 2007·The Journal of Clinical Investigation·Wenzheng ZhangBruce C Kone
May 30, 2008·American Journal of Physiology. Renal Physiology·Michael B ButterworthJohn P Johnson
Aug 21, 2008·The Journal of Biological Chemistry·Michael B ButterworthJohn P Johnson
Apr 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Peter KamenickyPhilippe Chanson
Nov 3, 2011·American Journal of Physiology. Endocrinology and Metabolism·Ryoichi TeruyamaWilliam E Armstrong
Jan 27, 2012·American Journal of Physiology. Cell Physiology·Yawar J QadriCatherine M Fuller
Nov 10, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Iván Hernández-DíazDiego Alvarez de la Rosa
Feb 18, 2016·The Journal of General Physiology·Gustavo FrindtLawrence G Palmer
Oct 28, 2019·American Journal of Physiology. Renal Physiology·Adam W WareFiona J McDonald
Jan 31, 1998·The Journal of Biological Chemistry·S DjelidiM Blot-Chabaud
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·S BergerG Schütz
Sep 14, 1999·The American Journal of Physiology·F Verrey
Jun 8, 1999·The Journal of Biological Chemistry·A Náray-Fejes-TóthG Fejes-Tóth
Sep 1, 2000·American Journal of Physiology. Renal Physiology·G H KimM A Knepper
Oct 8, 1999·The Journal of Clinical Investigation·S MasilamaniM A Knepper
Feb 24, 2001·American Journal of Physiology. Renal Physiology·N Farman, M E Rafestin-Oblin
Jul 15, 2004·The Journal of Biological Chemistry·Nathalie Marissal-ArvyPierre Mormède
May 19, 2007·Endocrinology·Cary Boyd, Anikó Náray-Fejes-Tóth
May 22, 2003·American Journal of Physiology. Renal Physiology·Muriel AubersonLaurent Schild
Jul 10, 2009·The Journal of Clinical Investigation·Michelle L GumzCharles S Wingo
Sep 10, 2010·American Journal of Physiology. Renal Physiology·Lise BankirNadine Bouby
Feb 27, 2019·British Journal of Pharmacology·Lena LottigMartin Diener
May 5, 1999·American Journal of Respiratory Cell and Molecular Biology·G OtulakowskiH O'Brodovich
Jul 15, 2000·American Journal of Physiology. Renal Physiology·C A EcelbargerM A Knepper
May 16, 2001·American Journal of Physiology. Renal Physiology·H HagerS Nielsen
Jul 10, 2001·American Journal of Physiology. Cell Physiology·B L Blazer-YostS J Rhodes
Dec 14, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Harry Robert BremnerGail Otulakowski
Jan 5, 2002·Physiological Reviews·Karl Kunzelmann, Marcus Mall

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