Noncovalent multivalent assembly of jun peptides on a leucine zipper dendrimer displaying fos peptides

Organic Letters
Min Zhou, Indraneel Ghosh

Abstract

[reaction: see text] The synthesis and characterization of a new leucine-zipper dendrimer (LZD) is reported that displays four copies of the peptide corresponding to the coiled-coiled dimerization domain of Fos. Circular dichroism spectroscopy, fluorescence titration, and sedimentation equilibrium experiments demonstrate that Fos-LZD can noncovalently assemble four copies of the peptide corresponding to the coiled-coil domain of Jun. This work provides the basis for the future construction of noncovalently assembled multivalent protein assemblies displaying any protein of interest.

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Citations

Oct 7, 2009·Journal of the American Chemical Society·Sujan S ShekhawatIndraneel Ghosh
Nov 22, 2005·Advanced Drug Delivery Reviews·Ruth Duncan, Lorella Izzo
Aug 23, 2006·Chemical Biology & Drug Design·Scott C MeyerIndraneel Ghosh
Dec 15, 2006·Biopolymers·Min Zhou, Indraneel Ghosh
May 12, 2005·Chemical Reviews·Laia CrespoFernando Albericio
Nov 6, 2009·Bioconjugate Chemistry·Peter M H HeegaardNanna Skall Sorensen

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