PMID: 9182818Jun 1, 1997Paper

Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996

The Journal of Investigative Dermatology
R S SternPUVA Follow-Up Study

Abstract

There is concern about possible association between PUVA treatment and an increased risk of noncutaneous cancer. An alteration in the risk of cancer among persons with psoriasis has also been postulated. To test this hypothesis, for nearly two decades we have prospectively followed 1380 patients who first began PUVA treatment for psoriasis in 1975-1976. We compare the risk of noncutaneous cancer in our cohort with that expected based on general population incidence rates. The overall risk of noncutaneous cancer was nearly identical to that expected in general population. For three separate sites, we noted significant increases: thyroid cancer (RR = 3.57, 95% CI = 1.16-8.34), breast cancer (RR = 1.81, 95% CI = 1.19-2.64), and central nervous system neoplasms (RR = 2.80, 95% CI = 1.13-5.57). Since 1987, however, the risk of central nervous system neoplasms has not been elevated (RR = 0.00, 95% CI = 0.00-3.35) and the relative risk of breast cancer was lower than in the prior decade and not statistically significant. There was no association between higher levels of exposure to PUVA and the risk of any of these cancers. We did not detect any significant increase in the risk of lymphoma or leukemia. Our study does not support the h...Continue Reading

Citations

Mar 1, 2007·Expert Review of Clinical Immunology·Shanu Kohli KurdJoel M Gelfand
Oct 2, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·U WehkampM Weichenthal
Oct 11, 2003·Photodermatology, Photoimmunology & Photomedicine·Tsui C LingLesley E Rhodes
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Cécile M RonckersElaine Ron
Jul 17, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·C PouplardC Paul
Jun 29, 2013·Hereditary Cancer in Clinical Practice·Romuald MaleszkaTadeusz Dębniak
Dec 21, 2017·American Journal of Clinical Dermatology·Shamir GellerMeenal Kheterpal
Dec 25, 2002·The Tohoku Journal of Experimental Medicine·Zuhal HamurcuEkrem Aktas
Aug 10, 2011·Photochemistry and Photobiology·Ingrid EmeritPaulo Filipe
May 30, 2013·Carcinogenesis·Mahesh RamamoorthyVilhelm A Bohr
Dec 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·G BiondoC Massone
Sep 24, 2004·Dermatologic Therapy·Debra Lewkowicz, Alice B Gottlieb
Nov 23, 2019·Dermatologic Clinics·Katherine G Thompson, Noori Kim
Aug 22, 2020·Journal of the American Academy of Dermatology·Amrita GoyalMurali Janakiram

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